The characteristics of 527 discharged COVID-19 patients undergoing long-term follow-up in China.
The characteristics of 527 discharged COVID-19 patients undergoing long-term follow-up in China.
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中国527例出院长期随访的COVID-19患者的特征
DOI：
10.1016/j.ijid.2021.01.064
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Dong L
中科院分区：
文献类型：
--
作者：
Zhang J;Xu J;Zhou S;Wang C;Wang X;Zhang W;Ning K;Pan Y;Liu T;Zhao J;Dong L
2019年(新冠肺炎)冠状病毒病暴发近一年后，许多住院的新冠肺炎患者已经康复。然而，对出院患者的长期随访(>；2个月)知之甚少。本研究纳入2020年2月5日至3月11日出院的527例新冠肺炎患者。对这些患者的基本特征、影像特征、核酸检测结果和抗体水平进行了回顾。在527名出院患者中，32名(6.1%)在后续检查中再次检测到SARS-CoV-2核酸阳性，其中11例和4例分别需要粪便样本和肛拭子样本，而不是呼吸道样本。青少年比其他年龄组更容易感染复发，重复检测(RP)RNA试验的时间跨度较短(平均8.8天[6.0-9.0天])，而中年组则相反(平均17.5天[14.0-17.5天])。在RP组和非RP组(NRP组)的影像特征上也观察到类似的改善。出院后3个月和6个月抗体阴性率分别为14.2%和25.0%。抗体阴性的病例在出院后6个月的青少年患者中更为常见(40%vs.15.6%，P=0.03)。在527名出院患者中，共有6.1%的患者表现出RP状态，这可能比从其他样本中更容易从粪便样本中识别出来。鉴于SARS-CoV-2抗体的下降率，可能会发生再感染，特别是在青少年患者(18岁)。这些发现对新冠肺炎康复者的长期管理具有一定的指导意义。
Almost a year after the outbreak of coronavirus disease 2019 (COVID-19), many hospitalized COVID-19 patients have recovered. However, little is known about the long-term follow-up (> 2 months) of discharged patients. This study enrolled 527 discharged COVID-19 patients from 05 February to 11 March 2020. Basic characteristics, imaging features, nucleic acid detection results, and antibody levels of these patients were retrospectively reviewed. Of the 527 discharged patients, 32 (6.1%) had re-detectable positive (RP) nucleic acid results for SARS-CoV-2 during follow-up examinations, with 11 and four detections entailing stool samples and anal swabs, respectively, rather than respiratory samples. Juveniles were more susceptible to “infection recurrence” than other age groups, with shorter time spans for re-detectable positive (RP) RNA tests (an average of 8.8 days [6.0–9.0 days]), while the reverse was true for the middle-aged group (17.5 days on average [14.0–17.5 days]). Similar improvements in the imaging features of both RP and no RP (NRP) groups were observed. Negative antibody detections in patients at 3 and 6 months after discharge were 14.2% and 25.0%, respectively. Cases evidencing negative antibodies were more common among juvenile patients (40% vs. 15.6%, P = 0.03) 6 months post-discharge. A total of 6.1% of 527 discharged patients showed RP status, which may be easier to be identified from stool samples than from other samples. Given the dropping rate of SARS-CoV-2 antibodies, reinfection may happen, especially in juvenile patients (aged < 18 years). These findings have implications for the long-term management of recovered COVID-19 patients.
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影响因子：
--
作者：
An J;Liao X;Xiao T;Qian S;Yuan J;Ye H;Qi F;Shen C;Wang L;Liu Y;Cheng X;Li N;Cai Q;Wang F;Chen J;Li G;Cai Q;Liu Y;Wang Y;Zhang F;Fu Y;He Q;Tan X;Liu L;Zhang Z
通讯作者：
Zhang Z
影响因子：
10
作者：
Hui, DS;Joynt, GM;Sung, JJY
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Sung, JJY
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin
影响因子：
19.7
作者：
Joynt, GM;Antonio, GE;Ahuja, AT
通讯作者：
Ahuja, AT