Risk of respiratory hospital admission associated with modelled concentrations of Aspergillus fumigatus from composting facilities in England.
Risk of respiratory hospital admission associated with modelled concentrations of Aspergillus fumigatus from composting facilities in England.
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呼吸道入院风险与英格兰堆肥设施中烟曲霉的模拟浓度相关。
DOI：
10.1016/j.envres.2019.108949
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发表时间：
2020
影响因子：
8.3
通讯作者：
Roca-Barcelo A
中科院分区：
文献类型：
--
作者：
Roca-Barcelo A
生物气溶胶与堆肥相关的有害健康影响有关，并且从堆肥设施中以高浓度排放。我们使用模拟的烟曲霉菌浓度，一个很好的指标，生物气溶胶排放，以评估与制药相关的入院。如前所述，从2005年开始到2014年，对英格兰76个堆肥设施4公里范围内的普查输出区（COA）的每个堆肥场发放许可证的第一个整年的平均每日烟曲霉浓度进行了估计（威廉姆斯等人，2019年）。我们拟合了一个分层广义混合模型，以检查入院风险，主要诊断为（i）任何呼吸系统疾病，（ii）呼吸道感染，（iii）哮喘，（iv）COPD，（v）有机粉尘引起的疾病，（vi）囊性纤维化，与烟曲霉浓度的四分位数相关。模型包括一个随机截距为每个COA占过度分散，嵌套在堆肥设施，在其上的随机截距拟合占聚类的数据，调整年龄，性别，种族，贫困，烟草销售（吸烟代理）和交通负荷（作为代理交通相关的空气污染）。我们在9606个COA中纳入了249，748例与堆肥相关的住院患者和3163例囊性纤维化住院患者，其中76个COA的人口加权质心在4公里范围内，包括堆肥设施。调整混杂因素后，在暴露量的最高四分位数中，未观察到任何与癌症相关的（相对风险（RR）= 0.99; 95%置信区间（CI）0.96-1.01）或囊性纤维化（RR = 1.01; 95% CI 0.56-1.83）因COA住院的统计学显著影响。在所有呼吸道疾病亚组中观察到相似的结果。这项研究并没有提供证据证明那些生活在堆肥设施附近的人与堆肥相关的住院风险增加。然而，鉴于离散模型的局限性，不能完全排除风险。住院代表严重的呼吸道事件，因此需要进一步研究，以调查堆肥设施排放的生物气溶胶是否对不太严重的事件或呼吸道症状产生影响。
Bioaerosols have been associated with adverse respiratory-related health effects and are emitted in elevated concentrations from composting facilities. We used modelledAspergillus fumigatusconcentrations, a good indicator for bioaerosol emissions, to assess associations with respiratory-related hospital admissions. Mean dailyAspergillus fumigatusconcentrations were estimated for each composting site for first full year of permit issue from 2005 onwards to 2014 for Census Output Areas (COAs) within 4 km of 76 composting facilities in England, as previously described (Williams et al., 2019). We fitted a hierarchical generalized mixed model to examine the risk of hospital admission with a primary diagnosis of (i) any respiratory condition, (ii) respiratory infections, (iii) asthma, (iv) COPD, (v) diseases due to organic dust, and (vi) Cystic Fibrosis, in relation to quartiles ofAspergillus fumigatusconcentrations. Models included a random intercept for each COA to account for over-dispersion, nested within composting facility, on which a random intercept was fitted to account for clustering of the data, with adjustments for age, sex, ethnicity, deprivation, tobacco sales (smoking proxy) and traffic load (as a proxy for traffic-related air pollution). We included 249,748 respiratory-related and 3163 Cystic Fibrosis hospital admissions in 9606 COAs with a population-weighted centroid within 4 km of the 76 included composting facilities. After adjustment for confounders, no statistically significant effect was observed for any respiratory-related (Relative Risk (RR) = 0.99; 95% Confidence Interval (CI) 0.96–1.01) or for Cystic Fibrosis (RR = 1.01; 95% CI 0.56–1.83) hospital admissions for COAs in the highest quartile of exposure. Similar results were observed across all respiratory disease sub-groups. This study does not provide evidence for increased risks of respiratory-related hospitalisations for those living near composting facilities. However, given the limitations in the dispersion modelling, risks cannot be completely ruled out. Hospital admissions represent severe respiratory episodes, so further study would be needed to investigate whether bioaerosols emitted from composting facilities have impacts on less severe episodes or respiratory symptoms.
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霉菌、潮湿和肺部
影响因子：
2
作者：
Konomi Kobayashi;Manabu Suzuki;Shota Yamamoto;Keisuke Ueno;E. Miyawaki;I. Takazawa;A. Shiozawa;Teruhiko Sato;M. Hojo;H. Sugiyama
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DOI：
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DOI：
10.1016/j.wasman.2018.11.044
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2019
期刊：
Waste management (New York, N.Y.)
影响因子：
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作者：
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DOI：
--
发表时间：
2001
期刊：
影响因子：
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作者：
M. Browne;C. L. Ju;G. Recer;L. Kallenbach;J. Melius;Edward G. Horn
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