Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases.
Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases.
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DOI：
10.3390/nu10010042
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发表时间：
2018-01-05
期刊：
影响因子：
5.9
通讯作者：
Gil A
中科院分区：
文献类型：
--
作者：
Plaza-Díaz J;Ruiz-Ojeda FJ;Gil-Campos M;Gil A
儿童群体不断面临感染性和炎症性疾病的风险。感染的治疗，特别是胃肠道疾病的治疗，重点是口服或静脉补液、营养支持，在某些情况下使用抗生素。在过去的十年中，益生菌和合成菌用于预防和治疗各种急慢性传染病的应用急剧增加。益生菌微生物主要用于治疗，因为它们可以刺激肠道微生物生态系统的变化，改善宿主的免疫状态。益生菌的有益作用是由不同的机制介导的。这些机制包括益生菌增强肠道屏障功能、防止细菌转移和通过免疫受体级联信号调节炎症的能力，以及它们调节宿主肠道基因表达的能力。然而，就儿童肠道疾病而言，有关这些关键作用机制的信息很少，特别是免疫介导的作用机制。本文就益生菌和合成菌影响免疫系统的生物化学和分子机制作一综述。
The pediatric population is continually at risk of developing infectious and inflammatory diseases. The treatment for infections, particularly gastrointestinal conditions, focuses on oral or intravenous rehydration, nutritional support and, in certain case, antibiotics. Over the past decade, the probiotics and synbiotics administration for the prevention and treatment of different acute and chronic infectious diseases has dramatically increased. Probiotic microorganisms are primarily used as treatments because they can stimulate changes in the intestinal microbial ecosystem and improve the immunological status of the host. The beneficial impact of probiotics is mediated by different mechanisms. These mechanisms include the probiotics’ capacity to increase the intestinal barrier function, to prevent bacterial transferation and to modulate inflammation through immune receptor cascade signaling, as well as their ability to regulate the expression of selected host intestinal genes. Nevertheless, with respect to pediatric intestinal diseases, information pertaining to these key mechanisms of action is scarce, particularly for immune-mediated mechanisms of action. In the present work, we review the biochemical and molecular mechanisms of action of probiotics and synbiotics that affect the immune system.
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影响因子：
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作者：
Foye OT;Huang IF;Chiou CC;Walker WA;Shi HN
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影响因子：
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影响因子：
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