Central insulin sensitivity in male and female juvenile rats.
Central insulin sensitivity in male and female juvenile rats.
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DOI：
10.1016/j.yhbeh.2009.05.006
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发表时间：
2009-09
影响因子：
3.5
通讯作者：
Ross MG
中科院分区：
文献类型：
--
作者：
Keen-Rhinehart E;Desai M;Ross MG
青少年肥胖症的发病率正以惊人的速度增加。在成人中，中枢胰岛素给药可以更有效地降低男性下丘脑食欲诱发神经肽、食物摄入量和体重。由于生长速度和激素环境的差异，幼年动物的能量平衡调节机制本质上不同于成年动物。因此，我们试图确定幼年大鼠（4 周）的中央胰岛素治疗是否会对食物摄入产生与成年大鼠相似的性别依赖性影响。在光照周期的黑暗阶段开始之前，在注射icv盐水或胰岛素（0.01或0.1U）后测量24小时的食物摄入量。另外一组动物用于评估中枢胰岛素对下丘脑促食欲（NPY、AgRP）和厌食（POMC）神经肽 mRNA 表达的影响。无论是男性还是女性，胰岛素最初都会减少进餐量（前 4 小时），后来减少进餐频率（4-24 小时），以减少累积食物摄入量。与此一致，中枢胰岛素降低下丘脑 NPY 和 AgRP，并增加 POMC mRNA 表达。与成人研究相反，没有显示出性别差异。这些研究表明，青少年雌性和雄性对中枢胰岛素减食欲作用同样敏感，这可能是由于缺乏循环性腺激素所致。两性的厌食反应表明了治疗儿童肥胖的潜在药理学方法。
The incidence of juvenile obesity is increasing at an alarming rate. In adults, central insulin administration decreases hypothalamic orexigenic neuropeptides, food intake and body weight more effectively in males than females. Mechanisms regulating energy balance in juvenile animals are inherently different from those in adults due to differences in growth rates and hormonal milieu. Therefore, we sought to determine if central insulin treatment in juvenile rats (4 wk) would have similar sex-dependent effects on food intake as those reported in adult rats. Twenty four hour food intake was measured following icv saline or insulin (0.01 or 0.1 U) prior to the onset of dark phase of the light cycle. An additional set of animals was used to assess the effects of central insulin on hypothalamic orexigenic (NPY, AgRP) and anorexigenic (POMC) neuropeptide mRNA expression. In both males and females, insulin reduced meal size initially (first 4h) and later decreased meal frequency (4–24 h) to reduce cumulative food intake. Consistent with this, central insulin decreased hypothalamic NPY and AgRP and increased POMC mRNA expression. In contrast to adult studies, there were no demonstrated sex differences. These studies indicate that juvenile females and males are equally sensitive to central insulin anorexigenic effects, perhaps due to a lack of circulating gonadal hormones. The anorexigenic responsiveness of both genders suggests a potential pharmacologic approach to childhood obesity.
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影响因子：
9.8
作者：
Beloosesky, Ron;Gayle, Dave A.;Ross, Michael G.
通讯作者：
Ross, Michael G.
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Air, EL;Benoit, SC;Woods, SC
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Woods, SC
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CLARK, JT;KALRA, PS;KALRA, SP
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KALRA, SP
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