System-on-chip considerations for CMOS fluidic and biointerface applications
System-on-chip considerations for CMOS fluidic and biointerface applications
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CMOS 流体和生物界面应用的片上系统注意事项
DOI：
10.1109/iscas.2014.6865558
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
E. Smela
中科院分区：
文献类型：
--
作者：
T. Datta;P. Abshire;E. Smela
CMOS芯片越来越多地用于直接传感和与流体和生物系统的接口。用于样品采集、信号处理和读出的CMOS电路已经与各种传感器集成，以形成复杂的芯片上生物系统。然而，生物传感器和集成电路的不同要求带来了独特而棘手的技术挑战。从集成电路的角度来看，直接CMOS生物传感在以下方面带来了挑战：封装;材料选择;由于地形的物理设计约束; CMOS管芯的MEMS后处理;能量和功率限制;以及信号的传输和处理。从生物学的角度来看，直接CMOS生物传感在以下方面带来了挑战：流体集成;电化学效应;生物相容性;环境维护和表面处理，以支持细胞健康和功能;以及不透明样品的光学评估。我们将描述这些挑战并回顾经验教训。
CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. CMOS circuits for sample acquisition, signal processing, and readout have been integrated with various sensors to form complex biosystems-on-chip. However, distinct and vexing technical challenges arise from the disparate requirements of biosensors and integrated circuits. From the perspective of integrated circuits, direct CMOS biosensing creates challenges in: packaging; materials selection; physical design constraints due to topography; MEMS post-processing of CMOS die; energy and power limitations; and transfer and processing of signals. From the perspective of biology, direct CMOS biosensing creates challenges in: fluidic integration; electrochemical effects; biocompatibility; environmental maintenance and surface treatments to support cell health and function; and optical assessment of opaque samples. We will describe these challenges and review lessons learned.
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影响因子：
7.4
作者：
Heo, Yun Seok;Cabrera, Lourdes M.;Takayama, Shuichi
通讯作者：
Takayama, Shuichi
DOI：
--
发表时间：
1998-12
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
T. Seese;H. Harasaki;G. Saidel;C. Davies
通讯作者：
T. Seese;H. Harasaki;G. Saidel;C. Davies
影响因子：
14
作者：
Voskerician, G;Shive, MS;Langer, R
通讯作者：
Langer, R
影响因子：
4.3
作者：
Dardik, A;Chen, LL;Sumpio, BE
通讯作者：
Sumpio, BE