Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation.
Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation.
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DOI：
10.1016/j.bbcan.2009.02.001
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发表时间：
2009-08
影响因子：
11.2
通讯作者：
McNagny, Kelly M.
中科院分区：
文献类型：
--
作者：
Maltby, Steven;Khazaie, Khashayarsha;McNagny, Kelly M.
越来越多的人认为肿瘤浸润性骨髓细胞在肿瘤生长中起着积极的作用，肥大细胞是最早浸润发展中肿瘤的细胞类型之一。肥大细胞聚集在健康组织和恶性肿瘤之间的边界处，并且通常与肿瘤微环境中的血管密切相关。它们表达许多促血管生成化合物，并且可能在发展中的肿瘤内的血管生成中发挥早期作用。肥大细胞在伤口愈合过程中也重塑细胞外基质，并且这种功能在肿瘤生长中被颠覆，促进肿瘤扩散和转移。此外，肥大细胞通过抑制免疫排斥或引导免疫细胞募集来调节免疫应答，这取决于局部刺激。在这篇综述中，我们着重于肥大细胞在血管生成，组织重塑和免疫调节中的关键作用，并强调肥大细胞在肿瘤生长中发挥的不可或缺的作用的最新研究结果。新的发现表明，肥大细胞可以作为癌症治疗的新的治疗靶点，抑制肥大细胞功能可能导致肿瘤消退。
There is a growing acceptance that tumor-infiltrating myeloid cells play an active role in tumor growth and mast cells are one of the earliest cell types to infiltrate developing tumors. Mast cells accumulate at the boundary between healthy tissues and malignancies and are often found in close association with blood vessels within the tumor microenvironment. They express many pro-angiogenic compounds, and may play an early role in angiogenesis within developing tumors. Mast cells also remodel extracellular matrix during wound healing, and this function is subverted in tumor growth, promoting tumor spread and metastasis. In addition, mast cells modulate immune responses by dampening immune rejection or directing immune cell recruitment, depending on local stimuli. In this review, we focus on key roles for mast cells in angiogenesis, tissue remodeling and immune modulation and highlight recent findings on the integral role that mast cells play in tumor growth. New findings suggest that mast cells may serve as a novel therapeutic target for cancer treatment and that inhibiting mast cell function may lead to tumor regression.
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影响因子：
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通讯作者：
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