Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins
Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins
复制标题
CAR 与昼夜周期的其余部分之间独特且共同的遗传病因学的证据：对 14 岁双胞胎的研究
DOI：
10.1016/j.psyneuen.2015.12.022
复制
发表时间：
2016
影响因子：
3.7
通讯作者：
M. Boivin
中科院分区：
文献类型：
--
作者：
I. Ouellet;M. Brendgen;A. Girard;S. Lupien;G. Dionne;F. Vitaro;M. Boivin
总的来说，研究已经报道了遗传因素对清晨分泌的皮质醇的中等贡献，甚至在一天的晚些时候更小的估计。相比之下，皮质醇觉醒反应（CAR）显示出更强的遗传性估计，这促使假设皮质醇分泌的病因可能根据一天中的时间而变化。这种可能性的直接测试，然而，尚未被performed. ObjectiveDescription的具体和共同的病因的CAR，觉醒水平和皮质醇变化，从早晨到晚上在一个年龄同质样本的双胞胎adolescents.MethodsA共592名参与者的魁北克新生儿双胞胎研究，一个人口为基础的1995-1998年队列的家庭在加拿大双胞胎，收集了唾液在觉醒，30分钟后，在下午结束时，在晚上超过四个collectionday. ResultsMultivariateCholesky模型显示了具体和共同的来源之间的变异的CAR，觉醒和皮质醇昼夜变化。CAR具有最强的遗传力估计，在大多数情况下，与其他指标不重叠。相反，类似的幅度的遗传和环境的贡献，检测到在觉醒和昼夜变化，其中部分overlapped.ConclusionOur研究揭示了潜在的病因的CAR和其余的昼夜周期，这可能有助于确定调控基因和环境，并理清这些指标如何各自与身心健康之间的差异。
IntroductionBy and large, studies have reported moderate contributions of genetic factors to cortisol secreted in the early morning and even smaller estimates later in the day. In contrast, the cortisol awakening response (CAR) has shown much stronger heritability estimates, which prompted the hypothesis that the etiology of cortisol secretion may vary according to the time of day. A direct test of this possibility has, however, not yet been performed.ObjectiveTo describe the specific and common etiology of the CAR, awakening level and cortisol change from morning to evening in an age-homogenous sample of twin adolescents.MethodsA total of 592 participants of the Québec Newborn Twin Study, a population-based 1995–1998 cohort of families with twins in Canada, have collected saliva at awakening, 30 min later, at the end of afternoon and in the evening over four collection days.ResultsMultivariate Cholesky models showed both specific and common sources of variance between the CAR, awakening and cortisol diurnal change. The CAR had the strongest heritability estimates, which, for the most part, did not overlap with the other indicators. Conversely, similar magnitudes of genetic and environmental contributions were detected at awakening and for diurnal change, which partially overlapped.ConclusionOur study unraveled differences between the latent etiologies of the CAR and the rest of the diurnal cycle, which may contribute to identify regulatory genes and environments and detangle how these indicators each relate to physical and mental health.
影响因子：
2.2
作者：
Shirtcliff, Elizabeth A.;Allison, Amber L.;Armstrong, Jeffrey M.;Slattery, Marcia J.;Kalin, Ned H.;Essex, Marilyn J.
通讯作者：
Essex, Marilyn J.