Augmenter of Liver Regeneration Protects Renal Tubular Epithelial Cells From Ischemia-Reperfusion Injury by Promoting PINK1/Parkin-Mediated Mitophagy

Augmenter of Liver Regeneration Protects Renal Tubular Epithelial Cells From Ischemia-Reperfusion Injury by Promoting PINK1/Parkin-Mediated Mitophagy
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肝脏再生增强剂通过促进 PINK1/Parkin 介导的线粒体自噬保护肾小管上皮细胞免受缺血再灌注损伤

DOI:
10.3389/fphys.2020.00178
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发表时间:
2020-03
影响因子:
4
通讯作者:
Liu Qi
Liu Qi
中科院分区:
医学2区
文献类型:
--
作者:
Zhu Dong-Ju;Liao Xiao-Hui;Huang Wen-Qi;Sun Hang;Zhang Ling;Liu Qi

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缺血再灌注(I/R)是急性肾损伤(AKI)最常见的原因,可诱导肾上皮小管细胞凋亡。线粒体功能障碍是I/ r诱导细胞凋亡的主要原因之一。越来越多的证据表明
Ischemia–reperfusion (I/R) is the most common cause of acute kidney injury (AKI) and can induce apoptosis in renal epithelial tubule cells. Mitochondrial dysfunction is one of the main reasons for I/R-induced apoptosis. Accumulating evidence suggests that
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