Metals in particulate pollutants affect peak expiratory flow of schoolchildren.
Metals in particulate pollutants affect peak expiratory flow of schoolchildren.
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DOI：
10.1289/ehp.9531
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发表时间：
2007-03
影响因子：
10.4
通讯作者：
Kim DS
中科院分区：
文献类型：
--
作者：
Hong YC;Hwang SS;Kim JH;Lee KH;Lee HJ;Lee KH;Yu SD;Kim DS
颗粒污染物的金属成分对急性呼吸影响的作用尚未得到充分评价。此外，关于外源性物质代谢的遗传多态性对肺功能的影响知之甚少。本研究旨在评估与颗粒污染物中金属成分和谷胱甘肽S-转移酶M1和T1基因多态性相关的肺功能下降。我们研究了43名三到六年级的学生。每个学生每天测量三次呼气峰流速，持续42天。每天监测空气中的颗粒物浓度，并测量颗粒物中铁、锰、铅、锌和铝的浓度。使用从参与者口腔冲洗液中提取的DNA确定谷胱甘肽S-转移酶M1和T1遗传多态性。我们使用混合线性回归模型来估计呼气峰流速和颗粒空气污染物之间的关联。我们发现，儿童暴露于颗粒污染物后，呼气峰流速显著降低。在暴露于环境颗粒后1天显示出最显著的效果。颗粒中的锰和铅也降低了呼气峰流速。谷胱甘肽S-转移酶M1和T1基因多态性对最大呼气流速无显著影响。这项研究表明，颗粒污染物和金属，如锰和铅的颗粒与峰值呼气流速的递减。即使考虑谷胱甘肽S-转移酶的遗传多态性，这些影响也是稳健的。
The contribution of the metal components of particulate pollutants to acute respiratory effects has not been adequately evaluated. Moreover, little is known about the effects of genetic polymorphisms of xenobiotic metabolism on pulmonary function. This study was conducted to assess lung function decrement associated with metal components in particulate pollutants and genetic polymorphisms of glutathione S-transferase M1 and T1. We studied 43 schoolchildren who were in the 3rd to 6th grades. Each student measured peak expiratory flow rate three times a day for 42 days. Particulate air concentrations were monitored every day, and the concentrations of iron, manganese, lead, zinc, and aluminum in the particles were measured. Glutathione S-transferase M1 and T1 genetic polymorphisms were determined using DNA extracted from participant buccal washings. We used a mixed linear regression model to estimate the association between peak expiratory flow rate and particulate air pollutants. We found significant reduction in the peak expiratory flow rate after the children’s exposure to particulate pollutants. The effect was shown most significantly 1 day after exposure to the ambient particles. Manganese and lead in the particles also reduced the peak expiratory flow rate. Genetic polymorphisms of glutathione S-transferase M1 and T1 did not significantly affect peak expiratory flow rate. This study demonstrated that particulate pollutants and metals such as manganese and lead in the particles are associated with a decrement of peak expiratory flow rate. These effects were robust even with consideration of genetic polymorphisms of glutathione S-transferase.
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影响因子：
3.8
作者：
Hakim, IA;Harris, RB;Ali, IU
通讯作者：
Ali, IU
DOI：
10.1164/ajrccm.163.6.2006056
发表时间：
2001-05-01
影响因子：
24.7
作者：
Bergamaschi, E;De Palma, G;Mutti, A
通讯作者：
Mutti, A
影响因子：
3.3
作者：
HAYES, JD;STRANGE, RC
通讯作者：
STRANGE, RC
影响因子：
10.4
作者：
Gurgueira SA;Lawrence J;Coull B;Murthy GG;González-Flecha B
通讯作者：
González-Flecha B
影响因子：
4.2
作者：
Campbell, A;Becaria, A;Bondy, SC
通讯作者：
Bondy, SC