Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice.
Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice.
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DOI：
10.1002/art.37943
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发表时间：
2013-06
影响因子：
--
通讯作者：
Riches, David W. H.
中科院分区：
文献类型：
--
作者：
Keith, Rebecca C.;Sokolove, Jeremy;Edelman, Benjamin L.;Lahey, Lauren;Redente, Elizabeth F.;Holers, V. Michael;Sakaguchi, Shimon;Robinson, William H.;Riches, David W. H.
Rheumatoid arthritis is a sexually dimorphic inflammatory autoimmune disease with both articular and extra-articular disease manifestations including rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Low levels of testosterone have been linked to disease severity in men with rheumatoid arthritis and supplemental testosterone has been shown to improve symptoms of rheumatoid arthritis in both postmenopausal women and men with low testosterone. The mechanisms by which sex and sex steroids affect the immune system and autoimmunity are poorly understood. In this study we examined the protective effect of testicular-derived sex hormones on both joint and lung disease development in an autoimmune mouse model. Arthritis prevalence and severity were assessed in female, orchiectomized, sham orchiectomized, and intact male SKG mice over a 12 week period after intraperitoneal injection of zymosan. Lung tissues were evaluated by quantifying: cellular accumulation in bronchoalveolar lavage, collagen levels, and histology. An antigen microarray was used to evaluate autoantibody generation in each condition. Female SKG mice developed arthritis and lung disease with increased prevalence and severity when compared to intact male mice. The absence of testosterone after orchiectomy led to increased arthritis, lung disease and autoantibody generation in orchiectomized male mice compared to intact male mice. SKG mice represent an authentic sexually dimorphic mouse model of both the joint and lung disease seen in rheumatoid arthritis. Testosterone protects against the development of joint and lung disease in male SKG mice.
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影响因子：
--
作者：
Sokolove, Jeremy;Zhao, Xiaoyan;Chandra, Piyanka E.;Robinson, William H.
通讯作者：
Robinson, William H.
影响因子：
27.4
作者：
Booij, A;Biewengabooij, CM;Bijlsma, JWJ
通讯作者：
Bijlsma, JWJ
影响因子：
15.9
作者：
Kuhn, KA;Kulik, L;Holers, VM
通讯作者：
Holers, VM
影响因子：
1.7
作者：
Keith, Rebecca C.;Powers, Jennifer L.;Riches, David W. H.
通讯作者：
Riches, David W. H.
DOI：
10.1530/acta.0.0780258
发表时间：
1975-01-01
期刊：
ACTA ENDOCRINOLOGICA
影响因子：
--
作者：
NAKASHIMA, A;KOSHIYAMA, K;MATSUMOTO, K
通讯作者：
MATSUMOTO, K