Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction.
Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction.
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DOI：
10.1016/j.tcm.2011.11.006
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发表时间：
2010-10
影响因子：
9.3
通讯作者：
Liao, James K.
中科院分区：
文献类型：
--
作者：
Li, Yuxin;Hiroi, Yukio;Liao, James K.
Notch信号通路通过局部的细胞-细胞相互作用，控制胚胎和成体生命期间的组织形成和稳态。在心脏中，Notch 1在多种细胞类型中表达，如心肌细胞、平滑肌细胞和内皮细胞。在心肌细胞中，Notch 1在增殖的胚胎和未成熟心肌细胞中被激活，并且在出生后发育期间在心肌中下调。然而，成年心肌中的Notch信号可以响应于心肌损伤而被瞬时激活，这表明Notch信号可能有助于心脏修复。事实上，Notch 1细胞内结构域的激活减轻了心肌损伤的严重程度，并改善了心肌血流动力学功能。相反，Notch 1基因的遗传消融，无论是全身性的还是骨髓来源的细胞，都会导致心肌梗死后心脏修复受损。本文就Notch信号通路的复杂机制及其在心肌梗死后心脏修复和再生中的作用作一综述。
Through local cell–cell interactions, Notch signaling pathway controls tissue formation and homeostasis during embryonic and adult life. In the heart, Notch1 is expressed in a variety of cell types such as cardiomyocytes, smooth muscle cells and endothelial cells. In cardiomyocytes, Notch1 is activated in proliferating embryonic and immature cardiomyocytes, and is downregulated in the myocardium during postnatal development. However, Notch signaling in the adult myocardium could be activated transiently in response to myocardial injury, suggesting that Notch signaling may contribute to cardiac repair. Indeed, activation of Notch1 intracellular domain blunts the severity of myocardial injury and improves myocardial hemodynamic function. Conversely, genetic ablation of the Notch1 gene, either systemically or in bone marrow-derived cells, leads to impaired cardiac repair following myocardial infarction. In this review, we will discuss the complex mechanisms of Notch signaling and its role in cardiac repair and regeneration after myocardial infarction.
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发表时间：
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影响因子：
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