Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study.
Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study.
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动脉[18F]-氟脱氧葡萄糖摄取定量的准确性：动力学模型研究。
DOI：
10.1007/s12350-020-02055-x
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Sadeghi,MehranM
中科院分区：
文献类型：
--
作者：
Toczek,Jakub;Wu,Jing;Hillmer,AnselT;Han,Jinah;Esterlis,Irina;Cosgrove,KellyP;Liu,Chi;Sadeghi,MehranM
Abstract2-deoxy-2- [18F] fluoro-d-glucose (FDG) PET is commonly used for the assessment of vessel wall inflammation. Guidelines for analysis of arterial wall FDG signal recommend the use of the average of maximal standardized uptake value (mean SUVmax) and target-to-blood (mean TBRmax) ratio. However, these methods have not been validated against a gold standard such as tissue activity ex vivo or net uptake rate of FDG (Ki) obtained using kinetic modeling. We sought to evaluate the accuracy of mean SUVmaxand mean TBRmaxfor aortic wall FDG signal quantification in comparison with the net uptake rate of FDG.MethodsDynamic PET data from 13 subjects without prior history of cardiovascular disease who enrolled in a study of vascular inflammation were used for this analysis. Ex vivo measurement of plasma activity was used as the input function and voxel-by-voxel Patlak analysis was performed witht* = 20 minute to obtain theKiimage. The FDG signal in the ascending aortic wall was quantified on PET images following recent guidelines for vascular imaging to determine mean SUVmaxand mean TBRmax.ResultsTheKiin the ascending aortic wall did not correlate with mean SUVmax(r= 0.10,P= NS), but correlated with mean TBRmax(r= 0.82,P< 0.001) (Figure 1B).KiandKi_maxstrongly correlated (R= 0.96,P< 0.0001) and similar toKi,Ki_maxdid not correlate with mean SUVmax(r= 0.17,P= NS), but correlated with mean TBRmax(r= 0.83,P< 0.001).ConclusionsKinetic modeling supports the use of mean TBRmaxas a surrogate for the net uptake rate of FDG in the arterial wall. These results are relevant to any PET imaging agent, regardless of the biological significance of the tracer uptake in the vessel wall.
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阳离子载体升高牛内皮细胞血管紧张素转换酶并哇巴因抑制。
DOI：
10.1016/0167-4889(90)90168-d
发表时间：
1990
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Dasarathy,Y;Fanburg,BL
通讯作者：
Fanburg,BL
DOI：
10.1016/0167-4889(89)90178-x
发表时间：
1989-01
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Y. Dasarathy;B. Fanburg
通讯作者：
Y. Dasarathy;B. Fanburg
DOI：
10.1016/s0021-9258(18)80158-2
发表时间：
1989-07
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kenneth E. BernsteinS;Brian M. Martins;A. S. Edwards;E. Bernstein
通讯作者：
Kenneth E. BernsteinS;Brian M. Martins;A. S. Edwards;E. Bernstein
细胞表面硫酸乙酰肝素参与脂蛋白脂肪酶与培养牛内皮细胞的结合
DOI：
--
发表时间：
1982
期刊：
影响因子：
--
作者：
嶋田 和幸
通讯作者：
嶋田 和幸
来自兔肺颗粒的血管紧张素转换酶。
DOI：
10.1073/pnas.71.5.1720
发表时间：
1974
影响因子：
11.1
作者：
R. Soffer;R. Reza;P. R. Caldwell
通讯作者：
P. R. Caldwell