Exercise-enhanced satellite cell proliferation and new myonuclear accretion in rat skeletal muscle.
Exercise-enhanced satellite cell proliferation and new myonuclear accretion in rat skeletal muscle.
复制标题
运动增强大鼠骨骼肌中的卫星细胞增殖和新的肌核增生。
DOI：
10.1152/jappl.2001.90.4.1407
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发表时间：
2001
影响因子：
3.3
通讯作者：
M. Plyley
中科院分区：
文献类型：
--
作者：
H. Smith;L. Maxwell;C. Rodgers;N. McKee;M. Plyley
通过使用复制肌纤维核的体内标记以及免疫细胞和组织化学技术，检查了成人骨骼肌运动诱发损伤后功能负荷增加对早期细胞再生事件的影响。未运动大鼠的比目鱼肌 (Sol) 卫星细胞增殖（纤维的 0.4 +/- 0.2%）在最初一轮减少跑步机运动后没有变化，但在每天进行两次相同任务后有所升高（1.0 +/- 0.2%，P < 或 = 0.01），但不是四次或七次。 7 天期间产生的肌核占未运动大鼠的 Sol、胫骨前肌和股中肌分离纤维中肌核的 0.9-1.9%。通过初始运动和随后的正常活动（肌核的 3.1-3.4%），以及持续的日常运动（4.2-5.3%），太阳肌和股中间肌中新肌核的积累得到增强（P < 或 = 0.05）。与组织学纤维损伤发生率较低以及每毫米纤维直径和肌核不变的观察结果一致，持续肌肉负荷引起的更大的新肌核增生可能有助于运动引起的损伤后纤维修复和再生的增强。
The effects of increased functional loading on early cellular regenerative events after exercise-induced injury in adult skeletal muscle were examined with the use of in vivo labeling of replicating myofiber nuclei and immunocyto- and histochemical techniques. Satellite cell proliferation in the soleus (Sol) of nonexercised rats (0.4 +/- 0.2% of fibers) was unchanged after an initial bout of declined treadmill exercise but was elevated after two (1.0 +/- 0.2%, P < or = 0.01), but not four or seven, daily bouts of the same task. Myonuclei produced over the 7-day period comprised 0.9-1.9% of myonuclei in isolated fibers of Sol, tibialis anterior, and vastus intermedius of nonexercised rats. The accretion of new myonuclei was enhanced (P < or = 0.05) in Sol and vastus intermedius by the initial exercise followed by normal activity (to 3.1-3.4% of myonuclei) and more so by continued daily exercise (4.2-5.3%). Observed coincident with a lower incidence of histological fiber injury and unchanged fiber diameter and myonuclei per millimeter, the greater new myonuclear accretion induced by continued muscle loading may contribute to an enhanced fiber repair and regeneration after exercise-induced injury.
影响因子：
3.3
作者：
ARMSTRONG, RB;OGILVIE, RW;SCHWANE, JA
通讯作者：
SCHWANE, JA