MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
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DOI：
10.1002/emmm.201100209
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发表时间：
2012-03
影响因子：
11.1
通讯作者：
Croce, Carlo M.
中科院分区：
文献类型：
--
作者：
Iorio, Marilena V.;Croce, Carlo M.
早期的研究表明，异常表达的microRNA是癌症等多种疾病的标志。MicroRNA表达谱显示与肿瘤的发生、进展和对治疗的反应相关，表明它们可能用作诊断、预后和预测生物标志物。此外，基于越来越多的研究表明microRNA可以作为潜在的致癌基因或抑癌基因发挥作用，目的是改善疾病反应并提高治愈率，最近已经开发了基于miRNA的抗癌疗法，无论是单独使用还是与当前的靶向疗法联合使用。使用microRNA方法的优势是基于其同时靶向参与细胞分化、增殖和存活的途径的多个效应物的能力。在这里，我们回顾了我们目前对microRNA参与癌症的认识，以及它们作为诊断，预后和治疗工具的潜力。
Early studies have shown how aberrantly expressed microRNAs are a hallmark of several diseases like cancer. MicroRNA expression profiling was shown to be associated with tumour development, progression and response to therapy, suggesting their possible use as diagnostic, prognostic and predictive biomarkers. Moreover, based on the increasing number of studies demonstrating that microRNAs can function as potential oncogenes or oncosuppressor genes, with the goal to improve disease response and increase cure rates, miRNA-based anticancer therapies have recently been exploited, either alone or in combination with current targeted therapies. The advantage of using microRNA approaches is based on its ability to concurrently target multiple effectors of pathways involved in cell differentiation, proliferation and survival. Here, we review our current knowledge about the involvement of microRNAs in cancer, and their potential as diagnostic, prognostic and therapeutic tools.
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影响因子：
14.9
作者：
Chen C;Ridzon DA;Broomer AJ;Zhou Z;Lee DH;Nguyen JT;Barbisin M;Xu NL;Mahuvakar VR;Andersen MR;Lao KQ;Livak KJ;Guegler KJ
通讯作者：
Guegler KJ
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
14.9
作者：
Betel D;Wilson M;Gabow A;Marks DS;Sander C
通讯作者：
Sander C
影响因子：
11.2
作者：
Brueckner, Bodo;Stresemann, Carlo;Lyko, Frank
通讯作者：
Lyko, Frank
影响因子：
30.8
作者：
Chang, Tsung-Cheng;Yu, Duonan;Mendell, Joshua T.
通讯作者：
Mendell, Joshua T.