Biomarkers of lung injury in cardiothoracic surgery.

Biomarkers of lung injury in cardiothoracic surgery.
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DOI:
10.1155/2015/472360
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发表时间:
2015
期刊:
影响因子:
--
通讯作者:
van Oeveren W
van Oeveren W
中科院分区:
医学4区
文献类型:
--
作者:
Engels GE;van Oeveren W

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肺功能障碍的诊断目前几乎完全基于大量的生理变化,但综合研究的重点是确定用于肺功能障碍早期诊断的生物标志物。在这里,我们讨论了在心胸外科手术中肺损伤的生物标志物的使用及其在围手术期检测轻微肺功能障碍的能力。中性粒细胞的脱粒产物通常被用作生物标志物,因为它们本身对肺组织具有有害作用。然而,这些物质不是肺特异性的。肺上皮特异性蛋白质提供了更多的特异性,并逐渐进入临床研究。
Diagnosis of pulmonary dysfunction is currently almost entirely based on a vast series of physiological changes, but comprehensive research is focused on determining biomarkers for early diagnosis of pulmonary dysfunction. Here we discuss the use of biomarkers of lung injury in cardiothoracic surgery and their ability to detect subtle pulmonary dysfunction in the perioperative period. Degranulation products of neutrophils are often used as biomarker since they have detrimental effects on the pulmonary tissue by themselves. However, these substances are not lung specific. Lung epithelium specific proteins offer more specificity and slowly find their way into clinical studies.
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