Cutting Edge: Lung-Resident T Cells Elicited by SARS-CoV-2 Do Not Mediate Protection against Secondary Infection.
Cutting Edge: Lung-Resident T Cells Elicited by SARS-CoV-2 Do Not Mediate Protection against Secondary Infection.
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DOI：
10.4049/jimmunol.2100608
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发表时间：
2021-11-15
期刊：
影响因子：
--
通讯作者：
Bosio CM
中科院分区：
文献类型：
--
作者：
Roberts LM;Jessop F;Wehrly TD;Bosio CM
Immunity to pulmonary infection typically requires elicitation of lung-resident T cells that subsequently confer protection against secondary infection. The presence of tissue resident T cells in SARS-CoV-2 convalescent patients is unknown. Using a sublethal mouse model of COVID-19, we determined if SARS-CoV-2 infection potentiated antigen-specific pulmonary resident CD4+ and CD8+ T cells responses and if these cells mediated protection against secondary infection. S protein specific T cells were present in resident and circulating populations. However, M and N protein specific T cells were only detected in the resident T cell pool. Using an adoptive transfer strategy, we found that T cells from SARS-CoV-2 immune animals did not protect naïve mice. These data indicate resident T cells are elicited by SARS-CoV-2 infection but are not sufficient for protective immunity.
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DOI：
10.1084/jem.20142101
发表时间：
2015-08-24
期刊：
The Journal of experimental medicine
影响因子：
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