Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer.
Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer.
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DOI：
10.1186/1471-2407-14-86
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发表时间：
2014-02-13
期刊：
影响因子：
3.8
通讯作者：
Rosser CJ
中科院分区：
文献类型：
--
作者：
Miyake M;Lawton A;Dai Y;Chang M;Mengual L;Alcaraz A;Goodison S;Rosser CJ
To determine the diagnostic and prognostic capability of urinary and tumoral syndecan-1 (SDC-1) levels in patients with cancer of the urinary bladder. SDC-1 levels were quantitated by enzyme-linked immunosorbent assay (ELISA) in 308 subjects (102 cancer subjects and 206 non-cancer subjects) to assess its diagnostic capabilities in voided urine. The performance of SDC-1 was evaluated using the area under the curve of a receiver operating characteristic curve. In addition, immunohistochemical (IHC) staining assessed SDC-1 protein expression in 193 bladder specimens (185 cancer subjects and 8 non-cancer subjects). Outcomes were correlated to SDC-1 levels. Mean urinary levels of SDC-1 did not differ between the cancer subjects and the non-cancer subjects, however, the mean urinary levels of SDC-1 were reduced in high-grade compared to low-grade disease (p < 0.0001), and in muscle invasive bladder cancer (MIBC) compared to non-muscle invasive bladder cancer (NMIBC) (p = 0.005). Correspondingly, preliminary data note a shift from a membranous cellular localization of SDC-1 in normal tissue, low-grade tumors and NMIBC, to a distinctly cytoplasmic localization in high-grade tumors and MIBC was observed in tissue specimens. Alone urinary SDC-1 may not be a diagnostic biomarker for bladder cancer, but its urinary levels and cellular localization were associated with the differentiation status of patients with bladder tumors. Further studies are warranted to define the potential role for SDC-1 in bladder cancer progression.
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影响因子：
2
作者：
Urquidi V;Chang M;Dai Y;Kim J;Wolfson ED;Goodison S;Rosser CJ
通讯作者：
Rosser CJ
影响因子：
6.9
作者：
Teng, Yvonne Hui-Fang;Aquino, Rafael S.;Park, Pyong Woo
通讯作者：
Park, Pyong Woo
影响因子：
6.2
作者：
Shah, L;Walter, KL;Powell, CA
通讯作者：
Powell, CA
关键评估用于分类或预测的生物标志物的准确性：研究设计标准。
影响因子：
10.3
作者：
Pepe, Margaret S.;Feng, Ziding;Janes, Holly;Bossuyt, Patrick M.;Potter, John D.
通讯作者：
Potter, John D.
影响因子：
6.2
作者：
Barbareschi, M;Maisonneuve, P;Doglioni, C
通讯作者：
Doglioni, C