Preliminary study of confounding factors of elastography and the application of fine-needle aspiration in thyroid nodules with indeterminate elastography.
Preliminary study of confounding factors of elastography and the application of fine-needle aspiration in thyroid nodules with indeterminate elastography.
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弹性成像混杂因素及细针穿刺在弹性成像不确定的甲状腺结节中的应用初探
DOI：
10.1038/s41598-017-18121-3
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发表时间：
2017-12-21
影响因子：
4.6
通讯作者：
Hu B
中科院分区：
文献类型：
--
作者：
Wu Q;Qu Y;Zang X;Li Y;Yi X;Wang Y;Hu B
研究实时超声弹性成像（RTE）的混杂因素，并评价超声（US）引导下FNA与传统US相比对弹性成像不确定的甲状腺结节的诊断性能。本研究纳入了244个因多种混杂因素（大小、深部、峡部或峡部旁、钙化、甲状腺炎、常规超声和RTE结果不一致）导致弹性成像不确定的结节，并计算了相应的恶性肿瘤患病率。此外，收集并比较了常规US和US-FNA数据。混杂因素中恶性肿瘤的发生率分别为74.1%、75.0%、73.3%、46.2%、27.3%和53.2%。甲状腺良、恶性结节的超声特征（边界、边缘、回声、回声均匀性、微钙化）差异有统计学意义（p < 0.05），多数敏感性较好，但特异性和准确性较差。超声细针穿刺诊断恶性肿瘤的敏感性为96.9%，特异性为99.1%，准确性为98.0%。鉴于不确定的RTE是不可避免的，由于几个混杂因素，恶性风险相当高，我们的研究表明，US-FNA是一个有价值的工具，结节与不确定的弹性成像，提高甲状腺恶性肿瘤的检出率。
To investigate confounding factors of real-time ultrasound elastography (RTE) and to evaluate the diagnostic performance of ultrasound (US)-guided FNA for thyroid nodules with indeterminate elastography compared with conventional US. This study included 244 nodules with indeterminate elastography caused by several confounding factors (large or small size, deep location, isthmic or paratracheal location, calcification, thyroiditis, conflicting results between conventional US and RTE), and corresponding prevalences of malignancy were calculated. Additionally, conventional US and US-FNA data were collected and compared. The prevalences of malignancy of confounding factors were 74.1%, 75.0%, 73.3%, 46.2%, 27.3%, and 53.2%, respectively. Sonographic features (border, margin, echogenicity, echohomogeneity, and microcalcification) were significantly different between benign and malignant thyroid nodules (p < 0.05), and most of them exhibited good sensitivity but unsatisfactory specificity and accuracy. While US-FNA exhibited better performance with a sensitivity of 96.9%, a specificity of 99.1% and an accuracy of 98.0% in the diagnosis of malignancy. Given that indeterminate RTE is inevitable with a rather high malignant risk due to several confounding factors, our study revealed that US-FNA was a valuable tool in nodules with indeterminate elastography by increasing the detection rate of thyroid malignancy.
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DOI：
10.1111/j.1365-2362.2009.02162.x
发表时间：
2009-08-01
影响因子：
5.5
作者：
Guth, S.;Theune, U.;Bamberger, C. M.
通讯作者：
Bamberger, C. M.
影响因子：
4.2
作者：
Gharib, Hossein;Papini, Enrico;Vitti, Paolo
通讯作者：
Vitti, Paolo
影响因子：
2.6
作者：
Bhatia, K. S. S.;Rasalkar, D. P.;Ahuja, A. T.
通讯作者：
Ahuja, A. T.
影响因子：
2.3
作者：
Sun, Jiasi;Cai, Jingyu;Wang, Xuemei
通讯作者：
Wang, Xuemei
影响因子：
6.6
作者：
Azizi, Ghobad;Keller, James;Malchoff, Carl
通讯作者：
Malchoff, Carl