Brain Renin‐Angiotensin Central Control of Secretion of Atrial Natriuretic Factor from the Heart
Brain Renin‐Angiotensin Central Control of Secretion of Atrial Natriuretic Factor from the Heart
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脑肾素-血管紧张素对心脏心房钠尿因子分泌的中枢控制
DOI：
10.1161/01.hyp.11.2_pt_2.i57
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发表时间：
1988
期刊：
影响因子：
8.3
通讯作者：
H. Imura
中科院分区：
文献类型：
--
作者：
H. Itoh;Takayuki Yamada;Narito More;S. Shiono;A. Sugawara;Yoshmko Sajto;M. Mukoyama;H. Arai;H. Imura
为阐明脑肾素-血管紧张素系统在心脏心钠素(ANF)分泌调节中的调节作用，本实验观察了脑室注射血管紧张素II对清醒自由大鼠血浆ANF水平的影响。给予血管紧张素II 10 0 ng和1无花果可显著增加容量负荷3ml生理盐水引起的心钠素分泌(峰值：对照组2 2 0±5 7pg/ml；血管紧张素II 10 0 ng，1110±320pg/ml，P<0.0 1；血管紧张素II 1μg，10 5 5±6 0pg/ml，P<0.0 1)。单独注射血管紧张素II对基础血浆ANF水平无明显影响。静脉注射血管加压素V1受体拮抗剂或脑室注射酚妥拉明可显著抑制中枢血管紧张素H诱导的心钠素分泌。这些结果表明，脑内肾素-血管紧张素系统通过刺激加压素的分泌或激活中枢α-肾上腺素能神经通路来调节ANF的分泌，以响应容量负荷。
To elucidate the modulatory role of the brain renln-angiotensin system in the regulation of the secretion of atrial natriuretic factor (ANF) from the heart, the effects of intracerebroventricular administration of angiotensin II on the plasma ANF level were examined in conscious unrestrained rats. Administration of angiotensin II in doses of 100 ng and 1 fig significantly enhanced ANF secretion induced by volume loading with infusion of 3 ml of saline (peak values of the plasma ANF level: control, 220 ± 57 pg/ml; angiotensin II 100 ng, 1110 ± 320 pg/ml, p < 0.01; angiotensin II 1μg, 1055 ± 60 pg/ml, p < 0.01). Injection of angiotensin II alone had no significant effect on the basal plasma ANF level. Central angiotensin H-induced ANF secretion was significantly attenuated by pretreatment with intravenous administration of the V1-receptor antagonist of vasopressin or intracerebroventricular administration of phentolamine. These results indicate that the brain renln-angiotensin system modulates ANF secretion in response to volume loading through the stimulation of vasopressin secretion or the activation of the central α-adrenergic neural pathway.
中央注射血管紧张素 II 会改变大鼠脑中儿茶酚胺的活性。
DOI：
10.1152/ajpregu.1983.244.2.r257
发表时间：
1983
期刊：
The American journal of physiology
影响因子：
--
作者：
Sumners,C;Phillips,MI
通讯作者：
Phillips,MI