New suggestions for the mechanical control of bone remodeling.
New suggestions for the mechanical control of bone remodeling.
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DOI：
10.1007/s00223-009-9242-x
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发表时间：
2009-07
影响因子：
4.2
通讯作者：
Weinkamer, R.
中科院分区：
文献类型：
--
作者：
Dunlop, J. W. C.;Hartmann, M. A.;Brechet, Y. J.;Fratzl, P.;Weinkamer, R.
关键词：
通过骨骼(重新)建模的过程，骨骼在我们的一生中不断更新。这一过程对于骨骼来说很重要，使其能够适应其机械环境，并修复日常生活中的损伤。适应被认为是通过控制骨形成和骨吸收细胞的机械敏感反应发生的。这份报告展示了一种方法，通过计算机模拟提取有关重塑控制方式的定量信息。骨吸收和骨沉积被描述为两个独立的随机过程，在这个过程中，一个离散的骨包从骨表面被取出或沉积。骨形成细胞和骨吸收细胞对局部机械刺激的反应由唯象重塑规则描述。我们的策略是测试不同的重建规则，并与真实骨骼的μ-CT测量结果进行比较，评估骨小梁结构的时间演变。特别是，我们测试了虚拟骨骼对防止骨骼退化的标准治疗策略的反应，即体力活动和减少骨吸收的药物。骨体积分数对骨吸收减少的不敏感性仅在模拟中观察到，重建规则包括机械刺激的激活屏障，高于该屏障的骨沉积被开启。这与通常使用的所谓懒惰地带的规则不一致。
Bone is constantly renewed over our lifetime through the process of bone (re)modeling. This process is important for bone to allow it to adapt to its mechanical environment and to repair damage from everyday life. Adaptation is thought to occur through the mechanosensitive response controlling the bone-forming and -resorbing cells. This report shows a way to extract quantitative information about the way remodeling is controlled using computer simulations. Bone resorption and deposition are described as two separate stochastic processes, during which a discrete bone packet is removed or deposited from the bone surface. The responses of the bone-forming and -resorbing cells to local mechanical stimuli are described by phenomenological remodeling rules. Our strategy was to test different remodeling rules and to evaluate the time evolution of the trabecular architecture in comparison to what is known from μ-CT measurements of real bone. In particular, we tested the reaction of virtual bone to standard therapeutic strategies for the prevention of bone deterioration, i.e., physical activity and medications to reduce bone resorption. Insensitivity of the bone volume fraction to reductions in bone resorption was observed in the simulations only for a remodeling rule including an activation barrier for the mechanical stimulus above which bone deposition is switched on. This is in disagreement with the commonly used rules having a so-called lazy zone.
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影响因子：
4.1
作者：
MORI, S;BURR, DB
通讯作者：
BURR, DB
影响因子：
4.1
作者：
PARFITT, AM
通讯作者：
PARFITT, AM
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM
影响因子：
4.8
作者：
Burger, EH;Klein-Nulend, J
通讯作者：
Klein-Nulend, J