A perspective on astrocyte regulation of neural circuit function and animal behavior.
A perspective on astrocyte regulation of neural circuit function and animal behavior.
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过去二十年的研究表明，星形胶质细胞与神经元密切相关，在神经回路的发育、运作和健康和疾病的适应中发挥着关键作用。然而，星形胶质细胞如何整合不同的神经元信号，在多个时间和空间尺度上调节神经回路结构和功能，并通过异常兴奋和分子输出影响动物行为或疾病仍不清楚。这个观点讨论了新的和最先进的方法，包括荧光指示剂，光学和化学致动器，遗传靶向工具，定量行为分析和计算方法，可能有助于解决这些长期存在的问题。它还解决了解释星形胶质细胞在神经回路调节和动物行为中的作用的复杂因素，如它们的异质性，代谢和胶质细胞间的通讯。对这些问题的研究应该提供一个更深层次的机制理解星形胶质细胞-神经元组装在神经回路功能，复杂行为和疾病中的作用。
Studies over the past two decades have demonstrated that astrocytes are tightly associated with neurons and play pivotal roles in neural circuit development, operation, and adaptation in health and disease. Nevertheless, precisely how astrocytes integrate diverse neuronal signals, modulate neural circuit structure and function at multiple temporal and spatial scales, and influence animal behavior or disease through aberrant excitation and molecular output remains unclear. This Perspective discusses how new and state-of-the-art approaches, including fluorescence indicators, opto- and chemogenetic actuators, genetic targeting tools, quantitative behavioral assays, and computational methods, might help resolve these longstanding questions. It also addresses complicating factors in interpreting astrocytes’ role in neural circuit regulation and animal behavior, such as their heterogeneity, metabolism, and inter-glial communication. Research on these questions should provide a deeper mechanistic understanding of astrocyte-neuron assemblies’ role in neural circuit function, complex behaviors, and disease.
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影响因子：
64.8
作者：
Bergles, DE;Roberts, JDB;Jahr, CE
通讯作者：
Jahr, CE
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25
作者：
Baraban M;Koudelka S;Lyons DA
通讯作者：
Lyons DA
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16.6
作者：
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通讯作者：
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影响因子：
16.2
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Agarwal A;Wu PH;Hughes EG;Fukaya M;Tischfield MA;Langseth AJ;Wirtz D;Bergles DE
通讯作者：
Bergles DE
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4.6
作者：
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通讯作者：
Rosello-Diez, Alberto