The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles.
The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles.
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DOI：
10.1084/jem.20040731
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发表时间：
2004-07-19
期刊：
影响因子：
--
通讯作者：
Kobzik L
中科院分区：
文献类型：
--
作者：
Arredouani M;Yang Z;Ning Y;Qin G;Soininen R;Tryggvason K;Kobzik L
肺泡巨噬细胞（AM）表达具有胶原结构的A类清道夫受体巨噬细胞受体（MARCO），但其在体内肺防御细菌和环境颗粒中的作用尚未研究。我们使用MARCO缺陷小鼠直接测试AM MARCO在对肺炎球菌感染和环境颗粒的先天防御中的体内作用。在肺炎球菌肺炎的小鼠模型中，MARCO−/−小鼠显示出从肺部清除细菌的能力受损，肺部炎症和细胞因子释放增加，存活率降低。肺炎链球菌的体外结合和MARCO−/− AM对未调理颗粒的体内摄取显著受损。用“惰性”环境颗粒TiO 2处理的MARCO−/−小鼠显示出增强的炎症和趋化因子表达，表明MARCO介导的AM对惰性颗粒的清除阻止了其他肺细胞引发的炎症反应。我们的研究结果指出，MARCO在建立有效和适当调节的先天免疫反应对吸入颗粒物和空气中的病原体的重要作用。
Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied. We used MARCO-deficient mice to directly test the in vivo role of AM MARCO in innate defense against pneumococcal infection and environmental particles. In a murine model of pneumococcal pneumonia, MARCO−/− mice displayed an impaired ability to clear bacteria from the lungs, increased pulmonary inflammation and cytokine release, and diminished survival. In vitro binding of Streptococcus pneumoniae and in vivo uptake of unopsonized particles by MARCO−/− AMs were dramatically impaired. MARCO−/− mice treated with the “inert” environmental particle TiO2 showed enhanced inflammation and chemokine expression, indicating that MARCO-mediated clearance of inert particles by AMs prevents inflammatory responses otherwise initiated by other lung cells. Our findings point to an important role of MARCO in mounting an efficient and appropriately regulated innate immune response against inhaled particles and airborne pathogens.
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影响因子：
15.3
作者：
Palecanda, A;Paulauskis, J;Al-Mutairi, E;Imrich, A;Qin, G;Suzuki, H;Kodama, T;Tryggvason, K;Koziel, H;Kobzik, L
通讯作者：
Kobzik, L
巨噬细胞清道夫受体依赖性吞噬作用保护致命革兰氏阳性感染。
DOI：
10.1084/jem.191.1.147
发表时间：
2000-01-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Thomas CA;Li Y;Kodama T;Suzuki H;Silverstein SC;El Khoury J
通讯作者：
El Khoury J
DOI：
10.2174/1566524013363384
发表时间：
2001-11-01
期刊：
Current Molecular Medicine (Hilversum)
影响因子：
--
作者：
Palecanda, Aiyappa;Kobzik, Lester
通讯作者：
Kobzik, Lester
影响因子：
3.8
作者：
LINDENSCHMIDT, RC;DRISCOLL, KE;BELFIORE, KA
通讯作者：
BELFIORE, KA
影响因子：
9.6
作者：
Gleeson, K;Eggli, DF;Maxwell, SL
通讯作者：
Maxwell, SL