Mass drug administration and the sustainable control of schistosomiasis: an evaluation of treatment compliance in the rural Philippines.
Mass drug administration and the sustainable control of schistosomiasis: an evaluation of treatment compliance in the rural Philippines.
复制标题
大众药物管理局和血吸虫病的可持续控制：菲律宾农村治疗依从性的评估。
DOI：
10.1186/s13071-018-3022-2
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发表时间：
2018-07-31
影响因子：
3.2
通讯作者：
Ross AG
中科院分区：
文献类型：
--
作者：
Inobaya MT;Chau TN;Ng SK;MacDougall C;Olveda RM;Tallo VL;Landicho JM;Malacad CM;Aligato MF;Guevarra JB;Ross AG
预防性化疗是目前全球血吸虫病控制策略。世卫组织的目标覆盖率是学龄儿童至少75%。在菲律宾，报告的全国覆盖率（43.5%）远远低于世卫组织的目标。本研究探讨了与不遵守大规模药物管理的相关因素。2015年，在菲律宾北方萨马尔省的2189名成年人中进行了一项横断面调查，使用结构化面对面调查问卷。在最后一轮治疗中，不依从大规模药物给药（MDA）的总体比例为27%。女性（aOR = 1.67，P = 0.033）更可能不依从。认为血吸虫病是由露天排便和卫生条件差引起的（aOR = 1.41，P = 0.015）和饮用不洁水引起的（aOR = 2.09，P = 0.001）更容易拒绝治疗。血吸虫病能否治愈（aOR = 2.39，P = 0.033），对吡喹酮不良反应的恐惧（aOR = 1.94，P = 0.021），对替代治疗形式的误解（aOR = 1.45，P = 0.037）和吡喹酮用于除驱虫以外的目的（aOR = 2.15，P = 0.021）均与较高的不依从率相关。相反，农民身份（aOR = 0.62，P =0.038）、参与过MDA（aOR = 0.30，P < 0.001）、了解过即将发生的MDA（aOR = 0.08，P < 0.001）和听说过血吸虫病（aOR = 0.22，P = 0.045）均与不依从性减少显著相关。为了提高血吸虫病的药物依从性，迫切需要在进行MDA之前进行密集的健康教育活动，不仅提供疾病的具体信息，而且还处理有关传播，预防，治疗和药物副作用的普遍误解。
Preventive chemotherapy is the current global control strategy for schistosomiasis. The WHO target coverage rate is at least 75% for school-aged children. In the Philippines, the reported national coverage rate (43.5%) is far below the WHO target. This study examined the factors associated with non-compliance to mass drug administration. A cross-sectional survey was conducted in 2015 among 2189 adults in the province of Northern Samar, the Philippines using a structured face-to-face survey questionnaire. The overall rate of non-compliance to mass drug administration (MDA) in the last treatment round was 27%. Females (aOR = 1.67, P = 0.033) were more likely to be non-compliant. Respondents who believed that schistosomiasis was acquired by open defecation and poor sanitation (aOR = 1.41, P = 0.015), and by drinking unclean water (aOR = 2.09, P = 0.001) were more likely to refuse treatment. Uncertainties on whether schistosomiasis can be treated (aOR = 2.39, P = 0.033), their fear of adverse reactions to praziquantel (aOR = 1.94, P = 0.021), misconceptions about alternative forms of treatment (aOR = 1.45, P = 0.037), and that praziquantel is used for purposes other than deworming (aOR = 2.15, P = 0.021) were all associated with a higher odd of non-compliance. In contrary, being a farmer (aOR = 0.62, P =0.038), participation in past MDA (aOR = 0.30, P < 0.001), informed about impending MDA (aOR = 0.08, P < 0.001), and having heard of schistosomiasis (aOR = 0.22, P = 0.045) were all significantly associated with reduced non-compliance. To improve drug compliance for schistosomiasis there is an urgent need for intensive health education campaigns before conducting MDA that would not only provide disease specific information, but also deal with prevailing misconceptions about transmission, prevention, treatment, and drug side-effects.
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影响因子：
8.1
作者：
Dabo A;Bary B;Kouriba B;Sankaré O;Doumbo O
通讯作者：
Doumbo O
影响因子：
3.8
作者：
Burnim M;Ivy JA;King CH
通讯作者：
King CH
影响因子：
3.7
作者：
Muhumuza, Simon;Olsen, Annette;Nuwaha, Fred
通讯作者：
Nuwaha, Fred
影响因子：
3.2
作者：
Farrell SH;Truscott JE;Anderson RM
通讯作者：
Anderson RM
影响因子：
4.5
作者：
Odhiambo, Gladys O.;Musuva, Rosemary M.;Mwinzi, Pauline N.
通讯作者：
Mwinzi, Pauline N.