The hierarchical emergence of worm-like chain behaviour from globular domain polymer chains.
The hierarchical emergence of worm-like chain behaviour from globular domain polymer chains.
复制标题
球状域聚合物链中蠕虫状链行为的分层出现。
作者：
Benjamin S. Hanson;D. Head;L. Dougan
生物有机体利用分层组织的结构来调节多个长度尺度上的机械行为，使微观物体产生宏观效应。在这些结构层次中，整个系统的物理行为不仅取决于组成子单元的内在力学性质，而且还取决于它们在三维空间中的组织。当这些亚基是多聚蛋白、胶体链或其他球状结构域聚合物时，Kratky-Porod模型通常被假设为单个亚基。因此，它隐含地断言聚合对象具有定义其灵活性的内在参数，持久性长度。然而，从实验中提取的持久性长度变化，往往是相对较小的。通过一系列的模拟上形成的球状亚基的聚合物链，我们表明，持久性长度本身是一个层次结构的属性，不仅相关的内在力学性能的基础单体亚基，但新兴的由于组织的不均匀的几何形状沿着的聚合物轮廓。
Biological organisms make use of hierarchically organised structures to modulate mechanical behaviour across multiple lengthscales, allowing microscopic objects to generate macroscopic effects. Within these structural hierarchies, the resultant physical behaviour of the entire system is determined not only by the intrinsic mechanical properties of constituent subunits, but also by their organisation in three-dimensional space. When these subunits are polyproteins, colloidal chains or other globular domain polymers, the Kratky-Porod model is often assumed for the individual subunits. Hence, it is implicitly asserted that the polymeric object has an intrinsic parameter, the persistence length, that defines its flexibility. However, the persistence lengths extracted from experiment vary, and are often relatively small. Through a series of simulations on polymer chains formed of globular subunits, we show that the persistence length itself is a hierarchical structural property, related not only to the intrinsic mechanical properties of the underlying monomeric subunits, but emerging due to the organisation of inhomogenous geometry along the polymer contour.
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影响因子：
4.6
作者：
Bharti, Bhuvnesh;Findenegg, Gerhard H.;Velev, Orlin D.
通讯作者：
Velev, Orlin D.
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通讯作者：
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影响因子：
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作者：
da Silva MA;Lenton S;Hughes M;Brockwell DJ;Dougan L
通讯作者：
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影响因子：
8.8
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Rivas-Pardo JA;Eckels EC;Popa I;Kosuri P;Linke WA;Fernández JM
通讯作者：
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