Efficacy of Bioenergetic Health Index to Predict Delirium After Major Abdominal Surgery in Elderly Patients: A Protocol for a Prospective Observational Cohort Study.
Efficacy of Bioenergetic Health Index to Predict Delirium After Major Abdominal Surgery in Elderly Patients: A Protocol for a Prospective Observational Cohort Study.
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生物能健康指数在老年患者大腹部手术后预测del妄的功效：前瞻性观察队列研究的方案。
DOI：
10.3389/fmed.2022.809335
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发表时间：
2022
影响因子：
3.9
通讯作者：
Hao, Xuechao
中科院分区：
文献类型：
--
作者：
Zhao, Yi;Liu, Juan;Ou, Mengchan;Hao, Xuechao
术后谵妄（POD）是手术后常见的疾病，严重威胁患者尤其是老年人的生活质量。这种综合征的多因素性使得很难确定一种理想的方法来预测个体风险。线粒体在POD的过程中起关键作用，包括手术引起的脑炎症和衰老相关的神经变性。由于BHI （Bioenergetic Health Index，生物能量健康指数）可以从个体血液分离的细胞中计算出来，代表患者的复合线粒体状态，我们假设个体外周血分离的单核细胞HBI可以预测老年患者重大非心脏手术后的POD。这是一项单中心的前瞻性、观察性单盲研究。124例年龄≥65岁，计划在全身麻醉下进行腹部大手术（bbb3h）的患者将被纳入研究。术前和术后谵妄将由训练有素的成员使用混乱评估法（CAM）进行评估。对于术后在ICU不能说话的患者，将使用重症监护病房混淆评估方法（CAM-ICU）。所有患者术前和术后1天在病房内静脉采血2次（1 - 2管，5ml /管）测量BHI。出院后，术后30天电话联系患者，确认出院后并发症的发生率。使用改良的Clavien-Dindo分类（CDC）方案，将并发症的严重程度分为轻度、中度、严重或致命。本研究已获得四川大学华西医院生物医学研究伦理委员会批准（主任委员邓少林教授，2021-502号）。研究数据将在提交给同行评议医学期刊的手稿以及提交给大会的摘要中传播。[www.ClinicalTrials.gov]，标识符[ChiCTR2100047554]。
Postoperative delirium (POD) is a common disorder following surgery, which seriously threatens the quality of patients’ life, especially the older people. The multifactorial manner of this syndrome has made it hard to define an ideal method to predict individual risk. Mitochondria play a key role in the process of POD, which include inflammatory on the brain caused by surgeries and aging related neurodegeneration. As BHI (Bioenergetic Health Index) could be calculated in cells isolated from an individual’s blood to represent the patient’s composite mitochondrial statue, we hypotheses that HBI of monocytes isolated from individual’s peripheral blood can predict POD after major non-cardiac surgery in elderly patients. This is a prospective, observational single-blinded study in a single center. 124 patients aged ≥ 65 years and scheduled for major abdominal surgery (>3 h) under general anesthesia will be enrolled. Preoperative and postoperative delirium will be assessed by trained members using Confusion Assessment Method (CAM). For patients unable to speak in the ICU after the surgery, Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) will be used. All patients will undergo venous blood sampling twice to measure BHI (1–2 tubes, 5 ml/tube): before the surgery and 1 day after surgery in wards. After discharge, patients will be contacted by telephone 30 days after surgery to confirm the incidence of post-discharge complications. The severity of complications will be categorized as mild, moderate, severe or fatal using a modified Clavien-Dindo Classification (CDC) scheme. The study has been approved by the Ethics Committee on Biomedical Research, West China Hospital of Sichuan University, Sichuan, China (Chairperson Prof Shaolin Deng, No. 2021-502). Study data will be disseminated in manuscripts submitted to peer-reviewed medical journals as well as in abstracts submitted to congresses. [www.ClinicalTrials.gov], identifier [ChiCTR2100047554].
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影响因子：
8.8
作者：
Gunther ML;Morandi A;Krauskopf E;Pandharipande P;Girard TD;Jackson JC;Thompson J;Shintani AK;Geevarghese S;Miller RR 3rd;Canonico A;Merkle K;Cannistraci CJ;Rogers BP;Gatenby JC;Heckers S;Gore JC;Hopkins RO;Ely EW;VISIONS Investigation, VISualizing Icu SurvivOrs Neuroradiological Sequelae
通讯作者：
VISIONS Investigation, VISualizing Icu SurvivOrs Neuroradiological Sequelae
DOI：
10.1016/j.athoracsur.2015.12.074
发表时间：
2016-05
期刊：
The Annals of thoracic surgery
影响因子：
--
作者：
Brown CH 4th;Laflam A;Max L;Lymar D;Neufeld KJ;Tian J;Shah AS;Whitman GJ;Hogue CW
通讯作者：
Hogue CW
影响因子：
8.8
作者：
Ely, EW;Margolin, R;Inouye, SK
通讯作者：
Inouye, SK
DOI：
10.1159/000358901
发表时间：
2014-01-01
期刊：
AGING: FACTS AND THEORIES
影响因子：
--
作者：
Kong, Yahui;Trabucco, Sally E.;Zhang, Hong
通讯作者：
Zhang, Hong
影响因子：
3.6
作者：
Drews, Tanja;Franck, Martin;Spies, Claudia D.
通讯作者：
Spies, Claudia D.