COVID-19-associated opportunistic infections: a snapshot on the current reports.
COVID-19-associated opportunistic infections: a snapshot on the current reports.
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DOI：
10.1007/s10238-021-00751-7
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发表时间：
2022-08
影响因子：
4.6
通讯作者：
Kenarkoohi A
中科院分区：
文献类型：
--
作者：
Abdoli A;Falahi S;Kenarkoohi A
2019 年新型冠状病毒病 (COVID-19) 的治疗仍然是一个复杂的挑战，特别是对于重症患者。在最近的研究中，免疫抑制治疗在控制 COVID-19 重症病例的细胞因子风暴综合征 (CSS) 方面显示出有希望的结果。然而，有充分证据表明，免疫抑制剂（例如皮质类固醇和细胞因子阻滞剂）会增加机会性感染的风险。另一方面，在COVID-19患者中报告了几种机会性感染，包括曲霉属、念珠菌属、新型隐球菌、卡氏肺孢子菌（卡氏肺孢子虫）、毛霉菌病、巨细胞病毒（CMV）、单纯疱疹病毒（HSV）、粪类圆线虫、结核分枝杆菌和弓形虫。本综述简要介绍了 COVID-19 患者中报告的主要机会性感染。因此，我们总结了近期针对 COVID-19 患者的临床试验中使用的主要免疫抑制剂的信息，以及这些治疗后发生机会性感染的风险。我们还讨论了 COVID-19 相关机会性感染 (CAOI) 诊断和治疗的主要挑战。在线版本包含可在 10.1007/s10238-021-00751-7 获取的补充材料。
Treatment of the novel Coronavirus Disease 2019 (COVID-19) remains a complicated challenge, especially among patients with severe disease. In recent studies, immunosuppressive therapy has shown promising results for control of the cytokine storm syndrome (CSS) in severe cases of COVID-19. However, it is well documented that immunosuppressive agents (e.g., corticosteroids and cytokine blockers) increase the risk of opportunistic infections. On the other hand, several opportunistic infections were reported in COVID-19 patients, including Aspergillus spp., Candida spp., Cryptococcus neoformans, Pneumocystis jiroveci (carinii), mucormycosis, Cytomegalovirus (CMV), Herpes simplex virus (HSV), Strongyloides stercoralis, Mycobacterium tuberculosis, and Toxoplasma gondii. This review is a snapshot about the main opportunistic infections that reported among COVID-19 patients. As such, we summarized information about the main immunosuppressive agents that were used in recent clinical trials for COVID-19 patients and the risk of opportunistic infections following these treatments. We also discussed about the main challenges regarding diagnosis and treatment of COVID-19-associated opportunistic infections (CAOIs). The online version contains supplementary material available at 10.1007/s10238-021-00751-7.
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DOI：
10.3390/curroncol28010094
发表时间：
2021-02-21
期刊：
Current oncology (Toronto, Ont.)
影响因子：
--
作者：
Barben J;Quipourt V;Vovelle J;Putot A;Manckoundia P
通讯作者：
Manckoundia P
影响因子：
0.8
作者：
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Kumanogoh A
DOI：
10.3390/pathogens10020157
发表时间：
2021-02-03
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
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通讯作者：
Kanj SS
影响因子：
5.5
作者：
Basso RP;Poester VR;Benelli JL;Stevens DA;Zogbi HE;Vasconcellos ICDS;Pasqualotto AC;Xavier MO
通讯作者：
Xavier MO
影响因子：
8.1
作者：
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通讯作者：
Alehashem, Maryam