First Candida auris Outbreak during a COVID-19 Pandemic in a Tertiary-Care Center in Lebanon.
First Candida auris Outbreak during a COVID-19 Pandemic in a Tertiary-Care Center in Lebanon.
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DOI：
10.3390/pathogens10020157
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发表时间：
2021-02-03
期刊：
影响因子：
--
通讯作者：
Kanj SS
中科院分区：
文献类型：
--
作者：
Allaw F;Kara Zahreddine N;Ibrahim A;Tannous J;Taleb H;Bizri AR;Dbaibo G;Kanj SS
耳念珠菌是一种新兴的真菌病原体，被认为是全球健康威胁。最近，人们越来越关注耐药性、难以识别以及根除问题。尽管全球各地（包括几个阿拉伯国家）都报告了疫情，但此前没有来自黎巴嫩的报告。地球仪。我们在此报告的第一例C。美国大学贝鲁特医学中心（黎巴嫩的一个三级保健中心）的耳道感染，描述了受影响患者的临床特征，以及感染控制调查和应用干预措施控制疫情。14例C.使用MALDI-TOF和VITEK 2- Compact系统鉴定的耳感染/定植在13周内报告。患者被送入四个独立的重症监护室。他们都是从急诊室来的，都有合并症。一半的患者在隔离C.耳。C.从血液（2个分离株）、尿液（3个分离株）、呼吸道（10个分离株）和皮肤（1个分离株）中分离耳道原虫。所有患者在分离出C.耳。6例患者接受抗真菌治疗，其余8例患者被认为是定植。从所有四个装置中采集环境培养物，未能从任何培养表面分离出微生物。感染预防和控制小组采取了一系列干预措施，以控制疫情。迅速发现和报告病例对于防止进一步的医院传播至关重要。需要建立一个国家标准化的感染控制登记册，以查明广泛的殖民化。
Candida auris is an emerging fungal pathogen considered as a global health threat. Recently there has been growing concern regarding drug resistance, difficulty in identification, as well as problems with eradication. Although outbreaks have been reported throughout the globe including from several Arab countries, there were no previous reports from Lebanon. We herein report the first cases of C. auris infection from the American University of Beirut Medical Center, a tertiary care center in Lebanon describing the clinical features of the affected patients in addition to the infection control investigation and applied interventions to control the outbreak. Fourteen patients with C. auris infection/colonization identified using MALDI-TOF and VITEK 2- Compact system were reported over a period of 13 weeks. Patients were admitted to four separate critical care units. All of them came through the emergency room and had comorbid conditions. Half of the patients were infected with COVID-19 prior to isolation of the C. auris. C. auris was isolated from blood (two isolates), urine (three isolates), respiratory tract (10 isolates) and skin (one isolate). All the patients had received broad spectrum antibiotics prior to isolation of C. auris. Six patients received antifungal treatment, while the remaining eight patients were considered colonized. Environmental cultures were taken from all four units and failed to isolate the organism from any cultured surfaces. A series of interventions were initiated by the Infection Prevention and Control team to contain the outbreak. Rapid detection and reporting of cases are essential to prevent further hospital transmission. A national standardized infection control registry needs to be established to identify widespread colonization.
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影响因子：
4.9
作者：
Ahmad, Suhail;Khan, Ziauddin;Joseph, Leena
通讯作者：
Joseph, Leena
影响因子：
3
作者：
Romera, David;Jairo Aguilera-Correa, John;Esteban, Jaime
通讯作者：
Esteban, Jaime
影响因子：
4.7
作者：
Al Maani, Amal;Paul, Hema;Al-Hatmi, Abdullah M. S.
通讯作者：
Al-Hatmi, Abdullah M. S.
影响因子：
7.1
作者：
Cortegiani A;Misseri G;Fasciana T;Giammanco A;Giarratano A;Chowdhary A
通讯作者：
Chowdhary A
影响因子：
9.4
作者：
Pfaller, M. A.;Boyken, L.;Diekema, D. J.
通讯作者：
Diekema, D. J.