Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population.
Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population.
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dcdc2 多态性与中国人群阅读能力正常变异的关联
DOI：
10.1371/journal.pone.0042969
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Shu H
中科院分区：
文献类型：
--
作者：
Zhang Y;Li J;Tardif T;Burmeister M;Villafuerte SM;McBride-Chang C;Li H;Shi B;Liang W;Zhang Z;Shu H
一些独立的研究支持DYX1C1与阅读障碍之间的联系，但它在一般阅读发展中的作用尚不清楚。本研究以284名5-11岁无亲缘关系的中国儿童为被试，研究了该基因对阅读的贡献，重点考察了该基因对阅读能力的影响。我们使用汉字阅读、汉字听写、拼写判断和视觉技能的量化方法来测试这种联系。在标记rs11629841上观察到与7岁和8岁儿童的正字法判断显著或轻微显著相关(所有P值均为0.020)。在9岁、10岁和11岁时，也观察到这种单核苷酸多态与汉字听写(所有P值和lt；0.013)显著相关。进一步的分析表明，与拼写技能的关联是对字符的特定组成部分的加工(P值和lt；0.046)。在rs3743205或rs57809907的SNP上均未发现关联。我们的研究结果表明，DYX1C1基因影响中国人的阅读发展，并支持该基因的普遍效应。
Several independent studies have supported the association of DYX1C1 with dyslexia, but its role in general reading development remains unclear. Here, we investigated the contribution of this gene to reading, with a focus on orthographic skills, in a sample of 284 unrelated Chinese children aged 5 to 11 years who were participating in the Chinese Longitudinal Study of Reading Development. We tested this association using a quantitative approach for Chinese character reading, Chinese character dictation, orthographic judgment, and visual skills. Significant or marginally significant associations were observed at the marker rs11629841 with children's orthographic judgments at ages 7 and 8 years (all P values<0.020). Significant associations with Chinese character dictation (all P values<0.013) were also observed for this single-nucleotide polymorphism (SNP) at ages 9, 10, and 11 years. Further analyses revealed that the association with orthographic skills was specific to the processing of specific components of characters (P values<0.046). No association was found at either SNP of rs3743205 or rs57809907. Our findings suggest that DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene.
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中国3-8岁儿童阅读发展与障碍的发展轨迹
DOI：
10.1111/j.1469-7610.2010.02311.x
发表时间：
2011-02-01
影响因子：
7.6
作者：
Lei, Lin;Pan, Jinger;Shu, Hua
通讯作者：
Shu, Hua
影响因子：
5.2
作者：
Marino, C;Giorda, R;Molteni, M
通讯作者：
Molteni, M
影响因子：
3.9
作者：
Kere, Juha
通讯作者：
Kere, Juha
书写汉字时的正字法缓冲：来自一名书写障碍患者的证据
影响因子：
3.4
作者：
Han, Zaizhu;Zhang, Yumei;Bi, Yanchao
通讯作者：
Bi, Yanchao
影响因子：
4.6
作者：
McBride-Chang, C;Kail, RV
通讯作者：
Kail, RV