Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.
Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.
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DOI：
10.4049/jimmunol.1300649
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发表时间：
2013-09-01
期刊：
影响因子：
--
通讯作者：
Tedder TF
中科院分区：
文献类型：
--
作者：
Maseda D;Candando KM;Smith SH;Kalampokis I;Weaver CT;Plevy SE;Poe JC;Tedder TF
具有表达IL-10 （B10细胞）功能的脾脏调节性B细胞亚群调节免疫反应和自身免疫性疾病的严重程度。然而，腹腔也含有相对高频率的功能性定义的IL-10-competent B10细胞。在这项研究中，腹腔B10细胞与脾脏B10细胞具有相似的细胞表面表型。然而，腹膜腔B10细胞在B细胞中的出现频率是脾脏、肠道或肠系膜淋巴结内的10倍，并且在表型明确的腹膜B1a>B1b>B2细胞亚群中出现的比例更高。B10细胞在腹腔内的发育或定位不依赖于共生菌群的存在、T细胞、IL-10或B10细胞IL-10的产生，也不依赖于胎儿肝脏或成人骨髓祖细胞来源的差异。腹膜腔B10细胞的BCR库是多种多样的，正如在脾脏中发生的那样，主要包括生殖系编码的VH和VL区域，通常在常规或B1 B细胞区室中发现。因此，产生IL-10的能力似乎是克隆多样性B细胞获得的内在功能特性。重要的是，在自发性和诱导性结肠炎模型中，腹腔B细胞产生IL-10通过调节中性粒细胞浸润、结肠炎致CD4+ T细胞活化和促炎细胞因子产生，显著降低疾病严重程度。因此，腹膜腔内数量小的B10细胞亚群具有调节功能，对维持胃肠道组织和免疫系统内的稳态很重要。
The spleen regulatory B cell subset with the functional capacity to express IL-10 (B10 cells) modulates both immune responses and autoimmune disease severity. However, the peritoneal cavity also contains relatively high frequencies of functionally-defined IL-10-competent B10 cells. In this study, peritoneal cavity B10 cells shared similar cell surface phenotypes with their spleen counterparts. However, peritoneal cavity B10 cells were 10-fold more frequent among B cells than occurred within the spleen, intestinal track or mesenteric lymph nodes and were present at higher proportions among the phenotypically-defined peritoneal B1a>B1b>B2 cell subpopulations. The development or localization of B10 cells within the peritoneal cavity was not dependent on the presence of commensal microbiota, T cells, IL-10 or B10 cell IL-10 production, or differences between their fetal liver or adult bone marrow progenitor cell origins. The BCR repertoire of peritoneal cavity B10 cells was diverse, as occurs in the spleen, and predominantly included germline-encoded VH and VL regions commonly found in either the conventional or B1 B cell compartments. Thereby, the capacity to produce IL-10 appears to be an intrinsic functional property acquired by clonally diverse B cells. Importantly, IL-10 production by peritoneal cavity B cells significantly reduced disease severity in spontaneous and induced models of colitis by regulating neutrophil infiltration, colitogenic CD4+ T cell activation and pro-inflammatory cytokine production during colitis onset. Thus, the numerically small B10 cell subset within the peritoneal cavity has regulatory function and is important for maintaining homeostasis within gastrointestinal tissues and the immune system.
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DOI：
10.4049/jimmunol.0803052
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Blair PA;Chavez-Rueda KA;Evans JG;Shlomchik MJ;Eddaoudi A;Isenberg DA;Ehrenstein MR;Mauri C
通讯作者：
Mauri C
DOI：
10.1084/jem.20092253
发表时间：
2010-06-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Feng T;Wang L;Schoeb TR;Elson CO;Cong Y
通讯作者：
Cong Y
DOI：
10.4049/jimmunol.1201427
发表时间：
2013-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Horikawa M;Weimer ET;DiLillo DJ;Venturi GM;Spolski R;Leonard WJ;Heise MT;Tedder TF
通讯作者：
Tedder TF
影响因子：
3.1
作者：
Aithal, GP;Craggs, A;Hudson, M
通讯作者：
Hudson, M
白介素10在抑制肠炎的调节T细胞功能中的重要作用。
影响因子：
15.3
作者：
Asseman, C;Mauze, S;Leach, M W;Coffman, R L;Powrie, F
通讯作者：
Powrie, F