Synthesis and application of quinazoline-oxazoline-containing (quinazox) ligands.
Synthesis and application of quinazoline-oxazoline-containing (quinazox) ligands.
复制标题
含喹唑啉-恶唑啉（喹唑啉）配体的合成及应用。
作者：
T. Fekner;H. Müller‐Bunz;P. Guiry
报道了一种可能的三齿P，N，N-配体的合成方法，该配体含有两个立体结构元素，分别与轴向手性喹唑啉亚基和中心手性2-恶唑啉亚基相连。这些新型杂化配体在Pd(0)催化的不对称烯丙基烷基化反应中的应用揭示了配对和失配的非对映异构体这一主要立体结构元素，以及恶唑啉R取代基对对映体选择性的影响(ee‘s高达81%)。[结构：见正文]
A practical synthesis of potentially tridentate P,N,N-ligands containing two stereogenic elements incorporated into the axially chiral Quinazolinap and centrally chiral 2-oxazoline subunits is reported. The application of these novel hybrid ligands in Pd(0)-catalyzed asymmetric allylic alkylation revealed the matched and mismatched diastereomer, dominant stereogenic element, as well as the effect of the oxazoline R substituent on the level of enantioselectivity (ee's up to 81%). [structure: see text]
影响因子：
15
作者：
Morgan, JB;Miller, SP;Morken, JP
通讯作者：
Morken, JP