Understanding the mechanisms of drug-associated interstitial lung disease.
Understanding the mechanisms of drug-associated interstitial lung disease.
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DOI：
10.1038/sj.bjc.6602065
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发表时间：
2004-08
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
药物由于直接药理作用、组织中的持久性或代谢，或通过反应性代谢物的产生而与肺损伤有关。这种明显的药物相关损伤的结果范围从细胞功能障碍到细胞死亡（细胞凋亡）和修复机制的改变，这些机制对于更换关键组织成分和功能至关重要。关于药物给药时间或药物相互作用如何干扰修复机制或调节肺毒性表达的知识有限。化疗药物和新型药物，例如针对表皮生长因子受体 (EGFR) 的药物，似乎会影响正常细胞和肿瘤细胞。然而，与化学疗法不同的是，化学疗法的作用是全身性的，并且直接由于生物转化或细胞损伤而产生，据推测，EGFR靶向药物的作用更有可能通过药理作用集中在上皮细胞上。此外，需要前瞻性地确定肺部不良反应发生的危险因素以及表明早期毒性的生物标志物。蛋白质组学通过鉴定血液样本中 ⩾1000 种蛋白质或肽，将有望确定担任这一角色的候选者。
Drugs have been implicated in lung injury as a result of direct pharmacological action, persistence or metabolism in the tissue, or via the production of a reactive metabolite or metabolites. The result of this apparent drug-associated injury ranges from cellular dysfunction through to cell death (apoptosis) and alteration of repair mechanisms that are essential in replacing critical tissue elements and function. There is limited knowledge on how timing of drug administration or drug interactions may interfere with the repair mechanisms or modulate the expression of pulmonary toxicity. Chemotherapeutic drugs and novel agents, such as those targeting the epidermal growth factor receptor (EGFR), appear to affect both normal and neoplastic cells. However, unlike chemotherapy, where the actions are systemic and directly as a result of biotransformation or cell injury, it has been postulated that effects of EGFR-targeting agents are more likely to be focused on epithelia via a pharmacological effect. Furthermore, risk factors for the development of adverse pulmonary reactions, as well as biological markers indicating incipient toxicity, need to be prospectively identified. Proteomics, through the identification of ⩾1000 proteins or peptides in blood samples, will hopefully identify candidates for this role.
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影响因子：
4.4
作者：
Hagimoto, N;Kuwano, K;Hara, N
通讯作者：
Hara, N
影响因子：
9.6
作者：
Castro, M;Veeder, MH;Jett, JR
通讯作者：
Jett, JR
DOI：
10.1165/ajrcmb/5.2.155
发表时间：
1991-08-01
影响因子：
6.4
作者：
KHALIL, N;OCONNOR, RN;GREENBERG, AH
通讯作者：
GREENBERG, AH
影响因子：
168.9
作者：
Inoue, A;Saijo, Y;Nukiwa, T
通讯作者：
Nukiwa, T
DOI：
10.1111/j.1445-5994.1985.tb04015.x
发表时间：
1985-01-01
期刊：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE
影响因子：
--
作者：
BELL, MR;MEREDITH, DJ;GILL, PG
通讯作者：
GILL, PG