Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis.
Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis.
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DOI：
10.1111/j.1365-2133.2009.09308.x
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Yosipovitch G
中科院分区：
文献类型：
--
作者：
Ishiuji Y;Coghill RC;Patel TS;Oshiro Y;Kraft RA;Yosipovitch G
关于支持疾病状态下慢性排尿经验的大脑机制知之甚少。使用使用动脉自旋标记（ASL）的新兴功能性磁共振成像（fMRI）技术，检查活动性特应性皮炎（AD）患者与健康对照者对组胺诱导瘙痒的大脑处理差异。在8例AD患者和7例健康受试者中用组胺离子导入法诱导瘙痒。我们发现AD患者和健康受试者在组胺诱导瘙痒的大脑处理方面存在显着差异。AD患者双侧前扣带皮层（ACC）、后扣带皮层（PCC）、压后扣带皮层和背外侧前额叶皮层（DLPFC）激活，对侧尾状核和壳核激活。与此相反，健康受试者激活初级运动皮层，初级躯体感觉皮层和上级顶叶。PCC和楔前叶表现出显着更大的活动在患者与健康受试者。在AD患者中，注意到ACC和对侧前脑的激活与组胺诱导的瘙痒强度以及疾病严重程度之间的脑激活百分比变化之间的显著相关性。此外，DLPFC活性与疾病严重程度之间存在相关性。我们的研究结果表明，ASL功能磁共振成像是一种很有前途的技术，以评估慢性瘙痒的大脑活动。AD患者急性瘙痒的大脑活动似乎与健康受试者不同。此外，涉及情感和情绪的皮层区域的活动与疾病严重程度的测量相关。
Little is known about brain mechanisms supporting the experience of chronic puritus in disease states. To examine the difference in brain processing of histamine-induced itch in patients with active atopic dermatitis (AD) vs. healthy controls with the emerging technique of functional magnetic resonance imaging (fMRI) using arterial spin labelling (ASL). Itch was induced with histamine iontophoresis in eight patients with AD and seven healthy subjects. We found significant differences in brain processing of histamine-induced itch between patients with AD and healthy subjects. Patients with AD exhibited bilateral activation of the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), retrosplenial cingulate cortex and dorsolateral prefrontal cortex (DLPFC) as well as contralateral activation of the caudate nucleus and putamen. In contrast, healthy subjects activated the primary motor cortex, primary somatosensory cortex and superior parietal lobe. The PCC and precuneus exhibited significantly greater activity in patients vs. healthy subjects. A significant correlation between percentage changes of brain activation was noted in the activation of the ACC and contralateral insula and histamine-induced itch intensity as well as disease severity in patients with AD. In addition, an association was noted between DLPFC activity and disease severity. Our results demonstrate that ASL fMRI is a promising technique to assess brain activity in chronic itch. Brain activity of acute itch in AD seems to differ from that in healthy subjects. Moreover, the activity in cortical areas involved in affect and emotion correlated to measures of disease severity.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
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