Mammary gland involution as an immunotherapeutic target for postpartum breast cancer.
Mammary gland involution as an immunotherapeutic target for postpartum breast cancer.
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DOI：
10.1007/s10911-014-9322-z
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发表时间：
2014-07
影响因子：
2.5
通讯作者：
Schedin, Pepper
中科院分区：
文献类型：
--
作者：
Fornetti, Jaime;Martinson, Holly A.;Betts, Courtney B.;Lyons, Traci R.;Jindal, Sonali;Guo, Qiuchen;Coussens, Lisa M.;Borges, Virginia F.;Schedin, Pepper
产后乳腺退化已被确定为肿瘤促进，并提出有助于增加转移率和产后乳腺癌患者的生存率差。在啮齿动物模型中，退化的乳腺微环境足以诱导增强的肿瘤细胞生长、局部侵袭和转移。产后复旧与伤口愈合有许多共同的属性，包括参与免疫反应的基因的上调和免疫细胞对组织的浸润。在啮齿动物模型中，用非甾体抗炎药（NSAID）治疗改善了退化的肿瘤促进作用，这与退化腺体的免疫环境有助于肿瘤促进一致。目前，免疫疗法正在研究作为乳腺癌治疗的一种手段，目的是确定增强抗肿瘤免疫应答的方法。在这里，我们审查产后乳腺退化的证据是一个独特的定义“热点”的促肿瘤免疫细胞浸润，并提出免疫治疗应探讨预防和治疗乳腺癌出现在这种环境中。
Postpartum mammary gland involution has been identified as tumor-promotional and is proposed to contribute to the increased rates of metastasis and poor survival observed in postpartum breast cancer patients. In rodent models, the involuting mammary gland microenvironment is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Postpartum involution shares many attributes with wound healing, including upregulation of genes involved in immune responsiveness and infiltration of tissue by immune cells. In rodent models, treatment with non-steroidal anti-inflammatory drugs (NSAIDs) ameliorates the tumor-promotional effects of involution, consistent with the immune milieu of the involuting gland contributing to tumor promotion. Currently, immunotherapy is being investigated as a means of breast cancer treatment with the purpose of identifying ways to enhance anti-tumor immune responses. Here we review evidence for postpartum mammary gland involution being a uniquely defined ‘hot-spot’ of pro-tumorigenic immune cell infiltration, and propose that immunotherapy should be explored for prevention and treatment of breast cancers that arise in this environment.
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