p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells.
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells.
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DOI：
10.1016/j.neulet.2007.03.026
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发表时间：
2007-05-11
影响因子：
2.5
通讯作者：
Killick, Richard
中科院分区：
文献类型：
--
作者：
Hooper, Claudie;Meimaridou, Eirini;Tavassoli, Mahvash;Melino, Gerry;Lovestone, Simon;Killick, Richard
P53和tau都与神经退行性疾病有关。在这里，我们通过Western blotting显示，与健康的老年对照组受试者相比，阿尔茨海默病患者的颞上回中P53的表达上调了大约2倍。此外，在HEK293a细胞中，P53可以诱导人2N4R tau在tau-1/AT8表位上的磷酸化。共聚焦显微镜显示，tau和p53在细胞内呈空间分离状态。Tau位于细胞骨架中，而P53位于细胞核中，说明P53对Tau磷酸化的影响是间接的。总而言之，这些发现对阿尔茨海默病和其他肌萎缩侧索硬化症相关的神经元死亡有影响。
p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies.
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影响因子：
16.2
作者：
GOEDERT, M;SPILLANTINI, MG;CROWTHER, RA
通讯作者：
CROWTHER, RA
DOI：
10.1006/bbrc.1997.6301
发表时间：
1997-03-17
影响因子：
3.1
作者：
Kitamura, Y;Shimohama, S;Taniguchi, T
通讯作者：
Taniguchi, T
影响因子：
3.3
作者：
BRION, JP;OCTAVE, JN;COUCK, AM
通讯作者：
COUCK, AM
影响因子：
5.3
作者：
da Costa, CA;Sunyach, C;Checler, F
通讯作者：
Checler, F
影响因子：
4.8
作者：
Davis, PK;Johnson, GVW
通讯作者：
Johnson, GVW