Thalamic neurometabolite alterations in patients with knee osteoarthritis before and after total knee replacement.
Thalamic neurometabolite alterations in patients with knee osteoarthritis before and after total knee replacement.
复制标题
膝关节骨关节炎患者全膝关节置换术前后丘脑神经代谢产物的变化。
DOI：
10.1097/j.pain.0000000000002198
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发表时间：
2021-07-01
期刊：
影响因子：
7.4
通讯作者：
Loggia ML
中科院分区：
文献类型：
--
作者：
Weerasekera A;Morrissey E;Kim M;Saha A;Lin Y;Alshelh Z;Torrado-Carvajal A;Albrecht D;Akeju O;Kwon YM;Bedair H;Chen AF;Napadow V;Schreiber K;Ratai EM;Edwards RR;Loggia ML
The weak association between disability levels and “peripheral” (i.e., knee) findings suggests that central nervous system alterations may contribute to the pathophysiology of knee osteoarthritis (KOA). Here, we evaluated brain metabolite alterations in KOA patients, before and after total knee arthroplasty (TKA), using 1H-magnetic resonance spectroscopy (MRS). Thirty-four pre-surgical KOA patients and 13 healthy controls were scanned using a PRESS sequence (TE=30ms, TR=1.7s, voxel size=15x15x15mm). Additionally, 13 patients were re-scanned 4.1±1.6 (mean±SD) weeks post-TKA. When using Creatine (Cr)-normalized levels, pre-surgical KOA patients demonstrated lower N-acetylaspartate (NAA) (p<0.001), and higher myoinositol (mIns) (p<0.001), and lower Choline (Cho) (p<0.05) compared to healthy controls. The mIns levels were positively correlated with pain severity scores (r=0.37, p<0.05). These effects reached statistical significance also using water-referenced concentrations, except for the Cho group differences (p≥0.067). Post-TKA, patients demonstrated an increase in NAA (p<0.01), which returned to the levels of healthy controls (p>0.05), irrespective of metric. Additionally, patients demonstrated post-surgical increases in Cr-normalized (p<0.001), but not water-referenced mIns, which were proportional to the NAA/Cr increases (r=0.61, p<0.05). Because mIns is commonly regarded as a glial marker, our results are suggestive of a possible dual role for neuroinflammation in KOA pain and post-TKA recovery. Moreover, the apparent post-surgical normalization of NAA a putative marker of neuronal integrity might implicate mitochondrial dysfunction, rather than neurodegenerative processes, as a plausible pathophysiological mechanism in KOA. More broadly, our results add to a growing body of literature suggesting that some pain-related brain alterations can be reversed after peripheral surgical treatment.
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DOI：
10.1016/j.bbi.2018.09.018
发表时间：
2019-01
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Albrecht DS;Forsberg A;Sandström A;Bergan C;Kadetoff D;Protsenko E;Lampa J;Lee YC;Höglund CO;Catana C;Cervenka S;Akeju O;Lekander M;Cohen G;Halldin C;Taylor N;Kim M;Hooker JM;Edwards RR;Napadow V;Kosek E;Loggia ML
通讯作者：
Loggia ML
DOI：
10.1038/nrneurol.2014.77
发表时间：
2014-06
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Bennett GJ;Doyle T;Salvemini D
通讯作者：
Salvemini D
影响因子：
4.6
作者：
Shigemura T;Kishida S;Eguchi Y;Ohtori S;Nakamura J;Kojima M;Masuda Y;Takahashi K
通讯作者：
Takahashi K
影响因子：
2.3
作者：
Bedson, John;Croft, Peter R.
通讯作者：
Croft, Peter R.
影响因子：
27.4
作者：
Duncan, R.;Peat, G.;Croft, P.
通讯作者：
Croft, P.