Proton magnetic resonance spectroscopy of the thalamus in patients with osteoarthritis of the hip.
Proton magnetic resonance spectroscopy of the thalamus in patients with osteoarthritis of the hip.
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DOI：
10.1302/2046-3758.11.2000018
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发表时间：
2012-01
影响因子：
4.6
通讯作者：
Takahashi K
中科院分区：
文献类型：
--
作者：
Shigemura T;Kishida S;Eguchi Y;Ohtori S;Nakamura J;Kojima M;Masuda Y;Takahashi K
本研究的目的是评估N-乙酰天冬氨酸的变化，在丘脑的髋关节骨关节炎患者使用质子磁共振波谱。9名髋关节骨关节炎患者（症状组，9名女性;平均年龄61.4岁（48至78岁））和9名健康志愿者（对照组，6名男性，3名女性;平均年龄30.0岁（26至38岁））接受质子磁共振波谱分析，以评估丘脑中N-乙酰天冬氨酸的变化。 髋关节骨关节炎患者症状髋关节对侧丘脑N-乙酰天门冬氨酸与肌酸加磷酸肌酸的比值明显低于对照组丘脑N-乙酰天门冬氨酸与肌酸加磷酸肌酸的比值（1.611（范围; 1.194-1.882）对1.355（范围; 1.043-1.502），p < 0.001）。并且，在髋关节骨关节炎患者有症状髋关节对侧丘脑中N-乙酰天冬氨酸与肌酸加磷酸肌酸的比值与疼痛持续时间之间检测到强负相关性（r =-0.83，p = 0.018）。我们使用质子磁共振波谱评估了髋关节骨关节炎患者丘脑中N-乙酰天冬氨酸与肌酸加磷酸肌酸的比值。我们的结论是，N-乙酰天冬氨酸肌酸加磷酸肌酸在丘脑对侧的髋关节骨关节炎的髋关节患者的丘脑显着低于对照组的丘脑，疼痛持续时间是密切相关的N-乙酰天冬氨酸肌酸加磷酸肌酸的比例下降。
The purpose of this study was to assess N-acetyl aspartate changes in the thalamus in patients with osteoarthritis of the hip using proton magnetic resonance spectroscopy. Nine patients with osteoarthritis of the hip (symptomatic group, nine women; mean age 61.4 years (48 to 78)) and nine healthy volunteers (control group, six men, three women; mean age 30.0 years (26 to 38)) underwent proton magnetic resonance spectroscopy to assess the changes of N-acetyl aspartate in the thalamus. The ratio of N-acetyl aspartate to creatine plus phosphocreatine in the thalamus contralateral to the symptomatic hip in patients with osteoarthritis of the hip was significantly lower than the ratio of N-acetyl aspartate to creatine plus phosphocreatine in the thalamus in the control group (1.611 (range; 1.194-1.882) vs 1.355 (range; 1.043-1.502), p < 0.001). And, a strong negative correlation was detected between the ratio of N-acetyl aspartate to creatine plus phosphocreatine in the thalamus contralateral to the symptomatic hip in patients with osteoarthritis of the hip and pain duration (r = -0.83, p = 0.018). We evaluated the ratio of N-acetyl aspartate to creatine plus phosphocreatine in the thalamus of patients with osteoarthritis of the hip by using proton magnetic resonance spectroscopy. We concluded that the ratio of N-acetyl aspartate to creatine plus phosphocreatine in the thalamus contralateral to the symptomatic hip in patients with osteoarthritis of the hip were significantly lower than those in the thalamus of the control group, and that pain duration was strongly related to the decrease of the ratio of N-acetyl aspartate to creatine plus phosphocreatine.
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影响因子：
19.7
作者：
KIMURA, H;FUJII, Y;ISHII, Y
通讯作者：
ISHII, Y
影响因子：
8.3
作者：
GRAHAM, GD;BLAMIRE, AM;PRICHARD, JW
通讯作者：
PRICHARD, JW
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
4.7
作者：
Bhakoo, KK;Pearce, D
通讯作者：
Pearce, D
影响因子：
19.7
作者：
SHONK, TK;MOATS, RA;ROSS, BD
通讯作者：
ROSS, BD