Cadmium exposure and incidence of diabetes mellitus--results from the Malmö Diet and Cancer study.
Cadmium exposure and incidence of diabetes mellitus--results from the Malmö Diet and Cancer study.
复制标题
DOI：
10.1371/journal.pone.0112277
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Engström G
中科院分区：
文献类型：
--
作者：
Borné Y;Fagerberg B;Persson M;Sallsten G;Forsgard N;Hedblad B;Barregard L;Engström G
镉是一种污染物，具有多种不良健康影响：肾功能障碍、骨质疏松症和骨折、癌症，可能还有心血管疾病。一些研究报道了镉与空腹血糖受损和糖尿病之间的关系。然而，这种关系是有争议的，缺乏纵向研究。前瞻性研究血镉是否与糖尿病发病率相关。研究人群包括4585名无糖尿病史的受试者（年龄46 - 67岁，60%为女性），他们在1991-1994年期间参加了马尔默饮食与癌症研究。血镉水平估计从红细胞压积和红细胞中的镉浓度。从国家和地方糖尿病登记册中确定了糖尿病发病病例。血镉浓度与基线检查时的血糖和胰岛素水平无关。然而，镉与既往吸烟者和当前吸烟者的HbA 1c呈正相关。在平均15.2±4.2年的随访期间，622例（299例男性和323例女性）被诊断为新发糖尿病。糖尿病的发病率与基线时血镉水平无显著相关性，无论男性还是女性。校正潜在混杂因素后，风险比（第四与第一四分位数）为1.11（95%置信区间0.82-1.49）。血镉水平升高与糖尿病发病率增加无关。HbA 1c和血镉水平之间的正相关可能与红细胞周转和吸烟有关。
Cadmium is a pollutant with multiple adverse health effects: renal dysfunction, osteoporosis and fractures, cancer, and probably cardiovascular disease. Some studies have reported associations between cadmium and impaired fasting glucose and diabetes. However, this relationship is controversial and there is a lack of longitudinal studies. To examine prospectively whether cadmium in blood is associated with incidence of diabetes mellitus. The study population consists of 4585 subjects without history of diabetes (aged 46 to 67 years, 60% women), who participated in the Malmö Diet and Cancer study during 1991–1994. Blood cadmium levels were estimated from hematocrit and cadmium concentrations in erythrocytes. Incident cases of diabetes were identified from national and local diabetes registers. Cadmium concentrations in blood were not associated with blood glucose and insulin levels at the baseline examination. However, cadmium was positively associated with HbA1c in former smokers and current smokers. During a mean follow-up of 15.2±4.2 years, 622 (299 men and 323 women) were diagnosed with new-onset of diabetes. The incidence of diabetes was not significantly associated with blood cadmium level at baseline, neither in men or women. The hazard ratio (4th vs 1st quartile) was 1.11 (95% confidence interval 0.82–1.49), when adjusted for potential confounders. Elevated blood cadmium levels are not associated with increased incidence of diabetes. The positive association between HbA1c and blood cadmium levels has a likely explanation in mechanisms related to erythrocyte turnover and smoking.
登录
查看更多内容
影响因子：
10.4
作者：
Åkesson A;Barregard L;Bergdahl IA;Nordberg GF;Nordberg M;Skerfving S
通讯作者：
Skerfving S
影响因子：
120.7
作者：
Melander, Olle;Maisel, Alan S.;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju
DOI：
10.1016/s0022-2143(03)00086-6
发表时间：
2003-07-01
期刊：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
影响因子：
--
作者：
Furne, JK;Springfield, JR;Levitt, MD
通讯作者：
Levitt, MD
影响因子：
6.2
作者：
Engstrom, Annette;Michaelsson, Karl;Akesson, Agneta
通讯作者：
Akesson, Agneta
影响因子：
11.1
作者：
Fagerberg, Bjorn;Bergstrom, Goran;Barregard, Lars
通讯作者：
Barregard, Lars