Adaptive Remodeling of the Neuromuscular Junction with Aging.
Adaptive Remodeling of the Neuromuscular Junction with Aging.
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DOI：
10.3390/cells11071150
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发表时间：
2022-03-29
期刊：
影响因子：
6
通讯作者：
Mifsud M
中科院分区：
文献类型：
--
作者：
Deschenes MR;Flannery R;Hawbaker A;Patek L;Mifsud M
衰老与神经肌肉系统在质量和功能上的逐渐退化有关。这一过程被称为“骨质疏松症”，本身就被认为是一种疾病，它与其他一些严重疾病有关，如II型糖尿病、骨质疏松症、关节炎、心血管疾病，甚至痴呆症。虽然骨质疏松症的分子病因仍未完全阐明，但最近的研究结果表明，神经肌肉接头(NMJ)是该疾病发生和发展的一个重要部位。这种连接运动神经元和它们所支配的肌肉纤维的突触被发现随着年龄的增长而退化，这两个因素都导致了与衰老有关的肌肉质量和功能的下降。在一些神经肌肉疾病中，如肌萎缩侧索硬化症(ALS)和Lambert-Eaton肌无力综合征(LEMS)，NMJ也表现出可塑性。在这里，描述了与衰老和疾病相关的NMJ的结构和功能退化，以及可能采取的有效缓解这种退化的措施，如果不是完全防止的话。
Aging is associated with gradual degeneration, in mass and function, of the neuromuscular system. This process, referred to as “sarcopenia”, is considered a disease by itself, and it has been linked to a number of other serious maladies such as type II diabetes, osteoporosis, arthritis, cardiovascular disease, and even dementia. While the molecular causes of sarcopenia remain to be fully elucidated, recent findings have implicated the neuromuscular junction (NMJ) as being an important locus in the development and progression of that malady. This synapse, which connects motor neurons to the muscle fibers that they innervate, has been found to degenerate with age, contributing both to senescent-related declines in muscle mass and function. The NMJ also shows plasticity in response to a number of neuromuscular diseases such as amyotrophic lateral sclerosis (ALS) and Lambert-Eaton myasthenic syndrome (LEMS). Here, the structural and functional degradation of the NMJ associated with aging and disease is described, along with the measures that might be taken to effectively mitigate, if not fully prevent, that degeneration.
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影响因子：
5.3
作者：
Barik, Arnab;Li, Lei;Mei, Lin
通讯作者：
Mei, Lin
DOI：
10.1093/geronj/44.2.b43
发表时间：
1989-03-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
ANDONIAN, MH;FAHIM, MA
通讯作者：
FAHIM, MA
影响因子：
3.7
作者：
Chai RJ;Vukovic J;Dunlop S;Grounds MD;Shavlakadze T
通讯作者：
Shavlakadze T
DOI：
10.1073/pnas.82.13.4544
发表时间：
1985-01-01
影响因子：
11.1
作者：
COVAULT, J;SANES, JR
通讯作者：
SANES, JR
DOI：
10.1073/pnas.1004956107
发表时间：
2010-06-08
影响因子：
11.1
作者：
An, Mahru C.;Lin, Weichun;Lee, Kuo-Fen
通讯作者：
Lee, Kuo-Fen