Multicystic meningioangiomatosis.
Multicystic meningioangiomatosis.
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多囊性脑膜血管瘤病
DOI：
10.1186/1471-2377-14-32
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发表时间：
2014-02-20
期刊：
影响因子：
2.6
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Li P;Cui G;Wang Y;Geng M;Wang Z
背景：脑膜血管瘤病是一种罕见的错构瘤病变。文献中仅报道了6例囊性MA。我们报告一例多囊性MA。一名21岁女性，无任何2型神经纤维瘤病的红斑，自10年以来出现难治性癫痫发作。脑磁共振成像显示右侧颞叶有一清晰的多囊性肿块，信号强度不均。患者在术中皮质电图（ECoG）辅助下切除病变和致痫皮质。组织病理学检查显示血管周围细胞呈袖带状增生，波形蛋白、D2-40和平滑肌肌动蛋白阳性。可见多发微囊，血管周围间隙增大，与蛛网膜腔结构相似。在反应性胶质瘤区首次发现透明化的胶原纤维与圆形同心脱细胞嗜酸性小片。随访2年，无临床症状，无复发。结论ma可能起源于大脑发育过程中被困在皮层实质中的蛛网膜和维管组织，而囊肿可能是由被困组织的血管周围间隙逐渐积聚的脑脊液所致。切除病变和致痫皮质不仅对病理诊断很重要，而且对癫痫控制也很重要，建议术中辅以ECoG。
BackgroundMeningioangiomatosis (MA) is a rare hamartomatous lesion. Only six cases of cystic MA have been reported in the literature.Case presentationWe present a case of multicystic MA. A 21-year-old woman without any stigmata of neurofibromatosis type 2 presented with intractable seizures since 10 years. Brain magnetic resonance imaging revealed a well-defined, multicystic mass with heterogeneous signal intensity in the right temporal lobe. The patient underwent resection of the lesion and of the epileptogenic cortex under intraoperative electrocorticography (ECoG) assistance. Histopathological examination showed proliferation of perivascular cells that were arranged in a cuff pattern and were positive for vimentin, D2-40 and smooth muscle actin. Mutiple microcysts and enlarged perivascular spaces were present, which was similar to the structure of the arachnoid cavity. Hyalinized collagen fibers with round concentric acellular eosinophilic lamellae within areas of reactive gliosis were noted for the first time in MA. The patient was followed up without any clinical symptoms or recurrence for 2 years.ConclusionMA may originate from arachnoid and vascular tissue trapped in the cortical parenchyma during brain development, and the cysts may have resulted from the gradual accumulation of cerebrospinal fluid in the perivascular spaces of the trapped tissue. Resection of the lesion and of the epileptogenic cortex is important not only for pathological diagnosis but also for seizure control, and intraoperative ECoG assistance is recommended.
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一名3岁患者的多灶性脑膜血管瘤病。
DOI：
10.3171/2012.9.peds1224
发表时间：
2012-12
期刊：
Journal of neurosurgery. Pediatrics
影响因子：
--
作者：
Jamil O;Ramkissoon S;Folkerth R;Smith E
通讯作者：
Smith E
影响因子：
1.9
作者：
Feng, Rui;Hu, Jie;Wang, Yin
通讯作者：
Wang, Yin
影响因子：
3.9
作者：
Kim, Na Rae;Cho, Seong Jin;Suh, Yeon-Lim
通讯作者：
Suh, Yeon-Lim
影响因子：
2.3
作者：
Wang, Y;Gao, X;Zhang, FL
通讯作者：
Zhang, FL
影响因子：
1.7
作者：
Asano, Eishi;Brown, Erik C.;Juhasz, Csaba
通讯作者：
Juhasz, Csaba