Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: a review.
Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: a review.
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DOI：
10.1007/978-3-7091-1192-5_42
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Provencio, J. Javier
中科院分区：
文献类型：
--
作者：
Provencio, J. Javier
蛛网膜下腔出血 (SAH) 后与血管痉挛相关的迟发性恶化 (DDAV)，通常称为血管痉挛，仍然是治疗困难的疾病，也是患者发病的主要原因。直到最近，人们的注意力还集中在缓解血管痉挛上。最近的证据表明，血管痉挛可能无法解释所有 DDAV 的发病率。人们对寻找其他潜在的治疗靶点重新产生了兴趣。炎症已成为新疗法研究的一个有前景的领域。在这篇综述中，我们将通过提出三个问题来探讨炎症是 DDAV 驱动因素的证据：1）如果炎症在疾病的发病机制中很重要，那么炎症反应的哪一部分涉及其中？ 2）SAH何时发生炎症？ 3）炎症发生在颅骨的哪个部位，脑脊液和脑膜，脑动脉还是大脑本身。
Delayed deterioration associated with vasospasm (DDAV) after subarachnoid hemorrhage (SAH), often called vasospasm, continues to be both a difficult entity to treat and a leading cause of morbidity in patients. Until recently, attention was focused at alleviating the vascular spasm. Recent evidence shows that vascular spasm may not account for all the morbidity of DDAV. There is renewed interest in looking for other potentially targets for therapy. Inflammation has become a promising area of research for new treatments. In this review, we will explore the evidence that inflammation is a driver of DDAV by asking three questions: 1) If inflammation is important in the pathogenesis of the disease, what part or parts of the inflammatory response are involved? 2) When does inflammation occur in the SAH? And 3) in what compartment of the skull does the inflammation occur, the cerebrospinal fluid and meninges, the cerebral arteries or the brain itself.
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