Neurocranium thickness mapping in early childhood.
Neurocranium thickness mapping in early childhood.
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DOI：
10.1038/s41598-020-73589-w
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发表时间：
2020-10-06
影响因子：
4.6
通讯作者：
Lepore N
中科院分区：
文献类型：
--
作者：
Gajawelli N;Deoni S;Shi J;Linguraru MG;Porras AR;Nelson MD;Tamrazi B;Rajagopalan V;Wang Y;Lepore N
脑颅在儿童早期迅速变化，以适应大脑的生长。发育障碍和环境因素，如睡眠姿势，可能会导致异常的脑神经成熟。因此，重要的是要了解这种结构是如何发展的，以便为早期发现异常提供基线。然而，由于缺乏可用的成像数据库，其解剖结构尚未在幼儿期得到很好的研究。在医院，CT通常用于在怀疑有病理时对脑颅进行成像，但电离辐射的存在使构建健康受试者的数据库变得更加困难。相反，在这项研究中，我们使用6个月至36个月的健康正常儿童的MRI数据集来研究脑颅的发育。在从MRI数据中提取其轮廓后，我们使用基于共形几何的分析管道来检测整个年龄段的局部厚度增长。这些变化将帮助我们了解颅骨发育与大脑的关系，并检测异常变化，从而为相关疾病提供更好的治疗策略。
The neurocranium changes rapidly in early childhood to accommodate the growing brain. Developmental disorders and environmental factors such as sleep position may lead to abnormal neurocranial maturation. Therefore, it is important to understand how this structure develops, in order to provide a baseline for early detection of anomalies. However, its anatomy has not yet been well studied in early childhood due to the lack of available imaging databases. In hospitals, CT is typically used to image the neurocranium when a pathology is suspected, but the presence of ionizing radiation makes it harder to construct databases of healthy subjects. In this study, instead, we use a dataset of MRI data from healthy normal children in the age range of 6 months to 36 months to study the development of the neurocranium. After extracting its outline from the MRI data, we used a conformal geometry-based analysis pipeline to detect local thickness growth throughout this age span. These changes will help us understand cranial bone development with respect to the brain, as well as detect abnormal variations, which will in turn inform better treatment strategies for implicated disorders.
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