Measuring the dynamic longitudinal cortex development in infants by reconstruction of temporally consistent cortical surfaces.
Measuring the dynamic longitudinal cortex development in infants by reconstruction of temporally consistent cortical surfaces.
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DOI：
10.1016/j.neuroimage.2013.12.038
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发表时间：
2014-04-15
期刊：
影响因子：
5.7
通讯作者：
Shen D
中科院分区：
文献类型：
--
作者：
Li G;Nie J;Wang L;Shi F;Gilmore JH;Lin W;Shen D
生后早期皮质纵向发育动态的定量研究对了解早期皮质的结构和功能发育具有重要意义。传统的方法通常独立地重建来自同一受试者的纵向图像的皮质表面，这通常产生不一致的皮质表面，从而导致皮质变化的不准确测量，特别是对于皮质发育的顶点映射。本文旨在解决这个问题，提出了一种方法来重建时间一致的皮层表面从纵向婴儿大脑MR图像，准确和一致的测量动态皮层发育的婴儿。具体地说，内部皮质表面的纵向发展首先由具有弹塑性性质的可变形生长片来建模，以建立内部皮质表面的纵向平滑对应。然后，建模的纵向内皮层表面的联合变形定位的内部和外部的皮层表面的时空变形表面的方法。该方法已被应用于13名健康婴儿，每个有6个连续的MR扫描获得在2周，3个月，6个月，9个月，12个月和18个月的年龄。实验结果表明，我们的方法与合并的纵向约束可以重建连续婴儿MR图像的动态皮质表面更一致，更准确地比以前发表的方法。通过使用我们的方法，我们第一次可以描述在生命的前18个月内的多个时间点的顶点纵向皮质厚度发展轨迹。具体而言，我们发现在此期间皮质厚度的高度年龄相关和区域异质性的发展轨迹，皮质厚度增加最多的是3至6个月（16.2%），最少的是9至12个月（不到0.1%）。具体而言，中央沟仅在6至9个月期间皮质厚度显著增加，枕叶皮质在0至9个月期间显著增加，而额叶、颞叶和顶叶皮质在出生后的前18个月内持续增长。成人样的皮质厚度的空间模式，一般存在于18个月的年龄。这些结果提供了详细的见解的动态轨迹的皮质厚度发展的婴儿。
Quantitative measurement of the dynamic longitudinal cortex development during early postnatal stages is of great importance to understand the early cortical structural and functional development. Conventional methods usually reconstruct the cortical surfaces of longitudinal images from the same subject independently, which often generate longitudinally-inconsistent cortical surfaces and thus lead to inaccurate measurement of cortical changes, especially for vertex-wise mapping of cortical development. This paper aims to address this problem by presenting a method to reconstruct temporally-consistent cortical surfaces from longitudinal infant brain MR images, for accurate and consistent measurement of the dynamic cortex development in infants. Specifically, the longitudinal development of the inner cortical surface is first modeled by a deformable growth sheet with elasto-plasticity property to establish longitudinally smooth correspondences of the inner cortical surfaces. Then, the modeled longitudinal inner cortical surfaces are jointly deformed to locate both inner and outer cortical surfaces with a spatial-temporal deformable surface method. The method has been applied to 13 healthy infants, each with 6 serial MR scans acquired at 2 weeks, 3 months, 6 months, 9 months, 12 months and 18 months of age. Experimental results showed that our method with the incorporated longitudinal constraints can reconstruct the longitudinally-dynamic cortical surfaces from serial infant MR images more consistently and accurately than the previously published methods. By using our method, for the first time, we can characterize the vertex-wise longitudinal cortical thickness development trajectory at multiple time points in the first 18 months of life. Specifically, we found the highly age-related and regionally-heterogeneous developmental trajectories of the cortical thickness during this period, with the cortical thickness increased most from 3 to 6 months (16.2%) and least from 9 to 12 months (less than 0.1%). Specifically, the central sulcus only underwent significant increase of cortical thickness from 6 to 9 months and the occipital cortex underwent significant increase from 0 to 9 months, while the frontal, temporal and parietal cortices grew continuously in this first 18 months of life. The adult-like spatial patterns of cortical thickness were generally present at 18 months of age. These results provided detailed insights into the dynamic trajectory of the cortical thickness development in infants.
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DOI：
10.1073/pnas.1308091110
发表时间：
2013-10-15
影响因子：
11.1
作者：
Chen, Chi-Hua;Fiecas, Mark;Kremen, William S.
通讯作者：
Kremen, William S.
影响因子：
11.2
作者：
CHI, JG;DOOLING, EC;GILLES, FH
通讯作者：
GILLES, FH
影响因子：
5.7
作者：
Awate, Suyash P.;Yushkevich, Paul A.;Gee, James C.
通讯作者：
Gee, James C.
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo
影响因子：
5.7
作者：
Kim, JS;Singh, V;Evans, AC
通讯作者：
Evans, AC