Thalamo-Cortical White Matter Underlies Motor Memory Consolidation via Modulation of Sleep Spindles in Young and Older Adults
Thalamo-Cortical White Matter Underlies Motor Memory Consolidation via Modulation of Sleep Spindles in Young and Older Adults
复制标题
丘脑皮质白质通过调节年轻人和老年人的睡眠纺锤体来巩固运动记忆
DOI：
10.1016/j.neuroscience.2018.12.049
复制
发表时间：
2019
期刊：
影响因子：
3.3
通讯作者：
S. Fogel
中科院分区：
文献类型：
--
作者：
C. Vien;A. Boré;A. Boutin;B. Pinsard;J. Carrier;J. Doyon;S. Fogel
充足的证据表明，巩固与新获得的运动序列相关的记忆痕迹是由随后的睡眠过程中的丘脑-皮质纺锤体活动，以及分布的皮质-纹状体网络的功能变化支持的。然而，到目前为止，还没有研究调查是否结构白色物质连接这些区域之间的影响运动序列记忆巩固与睡眠纺锤波。在这里，我们使用扩散加权成像（DWI）纤维束成像重建的主要分支的皮质-纹状体-苍白球-丘脑-皮质环的年轻和老年参与者谁是一个明确的手指序列学习任务训练之前和之后的白天小睡。因此，这使我们能够检查使用多导睡眠图记录测量的学习后睡眠纺锤波是否与巩固过程和这种特定的神经网络相互作用。我们的研究结果提供的证据证实了NREM 2丘脑-皮质睡眠纺锤波在运动序列记忆巩固中的关键作用，并表明这些神经生理事件的学习后变化与丘脑-皮质束中的白色物质特征有关。此外，我们证明，微结构沿着这一束间接涉及到离线增益性能通过增加纺锤体密度超过电机相关的皮层区域。这些结果表明，完整的丘脑-皮层的预测，通过其对睡眠纺锤波的产生的影响，可能代表的关键机制之一，调节运动序列学习后的睡眠依赖性离线增益的表达在健康成人。
Ample evidence suggests that consolidation of the memory trace associated with a newly acquired motor sequence is supported by thalamo-cortical spindle activity during subsequent sleep, as well as functional changes in a distributed cortico-striatal network. To date, however, no studies have investigated whether the structural white matter connections between these regions affect motor sequence memory consolidation in relation with sleep spindles. Here, we used diffusion weighted imaging (DWI) tractography to reconstruct the major fascicles of the cortico-striato-pallido-thalamo-cortical loop in both young and older participants who were trained on an explicit finger sequence learning task before and after a daytime nap. Thereby, this allowed us to examine whether post-learning sleep spindles measured using polysomnographic recordings interact with consolidation processes and this specific neural network. Our findings provide evidence corroborating the critical role of NREM2 thalamo-cortical sleep spindles in motor sequence memory consolidation, and show that the post-learning changes in these neurophysiological events relate specifically to white matter characteristics in thalamo-cortical fascicles. Moreover, we demonstrate that microstructure along this fascicle relates indirectly to offline gains in performance through an increase of spindle density over motor-related cortical areas. These results suggest that the integrity of thalamo-cortical projections, via their impact on sleep spindle generation, may represent one of the critical mechanisms modulating the expression of sleep-dependent offline gains following motor sequence learning in healthy adults.
DOI：
10.1016/j.mcna.2014.11.013
发表时间：
2015-03
期刊：
The Medical clinics of North America
影响因子：
--
作者：
Rodriguez JC;Dzierzewski JM;Alessi CA
通讯作者：
Alessi CA
影响因子：
2
作者：
Spencer, Rebecca M. C.;Gouw, Arvin M.;Ivry, Richard B.
通讯作者：
Ivry, Richard B.