No associations between serum concentrations of 25-hydroxyvitamin D and parathyroid hormone and depression among US adults
No associations between serum concentrations of 25-hydroxyvitamin D and parathyroid hormone and depression among US adults
复制标题
美国成年人血清 25-羟基维生素 D 和甲状旁腺激素浓度与抑郁症之间没有关联
DOI：
10.1017/s0007114510002588
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发表时间：
2010
影响因子：
3.6
通讯作者：
L. Balluz
中科院分区：
文献类型：
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作者：
Guixiang Zhao;E. Ford;Chaoyang Li;L. Balluz
尽管有证据表明维生素D缺乏可能在抑郁症中起作用，但对其相关性的研究得出了不同的结果。本研究旨在研究25-羟基维生素D （25(OH)D）和甲状旁腺激素（PTH）的血清浓度与美国成年人抑郁症之间的关系。采用2005 - 2006年全国健康与营养检查调查的横断面人群样本（包括3916名年龄≥20岁的参与者）。使用患者健康问卷-9诊断算法评估参与者的抑郁症状。采用多变量logistic回归模型探讨25(OH)D和PTH与抑郁症的关系。对于所有参与者，年龄调整后的患病率中，中度至重度抑郁症为5.3% (95% CI 4.3, 6.5) %，重度抑郁症为2.3% (95% CI 1.7, 3.1) %，轻度抑郁症为3.8% (95% CI 3.0, 4.6) %。虽然年龄调整后的患病率和未调整的中度至重度抑郁症或重度抑郁症的OR随着25(OH)D的增加呈线性下降（趋势P < 0.05），但在调整了多种潜在混杂因素（如人口统计学变量、生活方式因素和多种慢性疾病的共存）后，没有显著的相关性。经年龄调整的患病率和抑郁症的OR（未调整或调整）在PTH的四分位数上都没有显著差异。因此，与之前的一些研究结果相反，目前的研究结果并未显示25(OH)D和甲状旁腺激素的血清浓度与美国成年人中重度抑郁症、重度抑郁症或轻度抑郁症之间存在显著关联。然而，这些发现需要在未来的研究中进一步证实。
Although there is evidence that vitamin D deficiency may play a role in depression, studies done on the associations have yielded mixed results. The present study aimed to examine the associations between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) and the presence of depression among US adults. A cross-sectional, population-based sample (including 3916 participants aged ≥ 20 years) from the 2005–6 National Health and Nutrition Examination Survey was used. Participants' depressive symptoms were assessed using the Patient Health Questionnaire-9 diagnostic algorithm. The associations of 25(OH)D and PTH with depression were explored using multivariate logistic regression models. For all the participants, the age-adjusted prevalence was 5·3 (95 % CI 4·3, 6·5) % for having moderate-to-severe depression, 2·3 (95 % CI 1·7, 3·1) % for having major depression and 3·8 (95 % CI 3·0, 4·6) % for having minor depression. Although the age-adjusted prevalence and the unadjusted OR of having moderate-to-severe depression or major depression decreased linearly with increasing quartiles of 25(OH)D (P < 0·05 for trends), no significant associations remained after adjusting for multiple potential confounders such as demographic variables, lifestyle factors and coexistence of a number of chronic conditions. Neither the age-adjusted prevalence nor the OR (unadjusted or adjusted) of having depression differed significantly by the quartiles of PTH. Thus, in contrast to some of the previous findings, the present results did not show significant associations between serum concentrations of 25(OH)D and PTH and the presence of moderate-to-severe depression, major depression or minor depression among US adults. However, these findings need to be further confirmed in future studies.
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad