25-hydroxyvitamin D levels and the risk of mortality in the general population.
25-hydroxyvitamin D levels and the risk of mortality in the general population.
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DOI：
10.1001/archinte.168.15.1629
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发表时间：
2008-08-11
影响因子：
--
通讯作者：
Astor, Brad
中科院分区：
文献类型：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
在透析患者中，活性维生素D治疗与死亡率降低相关。观察数据表明，低25-羟基维生素D水平与糖尿病、高血压和癌症有关。然而，在一般人群中，低血清25-羟基维生素D（25（OH）D）水平是否与死亡率相关尚不清楚。我们测试了低25（OH）D水平与全因，癌症和心血管疾病（CVD）死亡率之间的关系，这些死亡率来自第三次全国健康和检查调查（NHANES III）相关死亡率文件中的13，331名全国代表性≥ 20岁的成年人。1988 - 1994年收集了参与者的维生素D水平，并被动跟踪了2000年的死亡率。在横断面多变量分析中，年龄增加、女性、非白人种族/民族、糖尿病、当前吸烟和较高的BMI均与25（OH）D缺乏的几率较高（25（OH）D的最低四分位数<17.8 ng/ml）独立相关，而更多的体力活动、维生素D补充和非冬季则呈负相关。在平均8.7年的随访中，有1806例死亡，其中777例死于CVD。在多变量模型中（根据基线人口统计学、季节、传统和新的CVD风险因素调整），与最高四分位数相比，25（OH）D水平<17.8 ng/ml与全因死亡率增加26%（1.26，95%CI 1.08 - 1.46）和人群归因风险3.1%相关。调整后的CVD和癌症死亡率模型显示风险较高，但无统计学意义。25（OH）D的最低四分位数（<17.8 ng/ml）与一般人群的全因死亡率独立相关。
In dialysis patients, activated vitamin D therapy is associated with reduced mortality. Observational data suggests that low 25-hydroxyl vitamin D levels are associated with diabetes mellitus, hypertension and cancers. However, whether low serum 25-hydroxyl vitamin D (25(OH)D) levels are associated with mortality in the general population is unknown. We tested the association of low 25(OH)D levels with all-cause, cancer and cardiovascular disease (CVD) mortality in 13,331 nationally representative adults ≥20 years old from the Third National Health and Examination Survey (NHANES III) Linked Mortality Files. Participant vitamin D levels were collected in 1988-1994 and individuals were passively followed for mortality through 2000. In cross-sectional multivariable analyses, increasing age, female sex, non-white race/ethnicity, diabetes, current smoking, and higher BMI were all independently associated with higher odds of 25(OH)D deficiency (lowest quartile of 25(OH)D <17.8 ng/ml), while greater physical activity, vitamin D supplementation and non-winter season were inversely associated. During a median 8.7 years of follow-up, there were 1806 deaths including 777 from CVD. In multivariable models (adjusted for baseline demographics, season, traditional and novel CVD risk factors), compared to the highest quartile, 25(OH)D levels <17.8 ng/ml were associated with a 26% increased rate of all-cause mortality (1.26, 95% CI 1.08-1.46) and a population attributable risk of 3.1%. The adjusted models of CVD and cancer mortality revealed a higher risk which was not statistically significant. The lowest quartile of 25(OH)D (<17.8 ng/ml) is independently associated with all-cause mortality in the general population.
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影响因子：
16.2
作者：
Ford, ES;Ajani, UA;Liu, S
通讯作者：
Liu, S
影响因子：
--
作者：
Martins, David;Wolf, Myles;Norris, Keith
通讯作者：
Norris, Keith
影响因子：
15.9
作者：
Li, YC;Kong, J;Cao, LP
通讯作者：
Cao, LP
影响因子：
19.6
作者：
Chonchol, M.;Scragg, R.
通讯作者：
Scragg, R.
影响因子：
13.2
作者：
Coresh, J;Astor, BC;Levey, AS
通讯作者：
Levey, AS