Prehypertensive and other variabilities also await treatment.
Prehypertensive and other variabilities also await treatment.
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高血压前期和其他变异也有待治疗。
DOI：
10.1016/j.amjmed.2006.02.045
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Schwartzkopff,Othild
中科院分区：
文献类型：
--
作者：
Halberg,Franz;Cornélissen,Germaine;Halberg,Julia;Schwartzkopff,Othild
收缩压在120到139毫米汞柱之间，舒张压在80到89毫米汞柱之间，通常被认为是正常的，但被描述为高血压前期，这与心血管疾病的风险增加有关。1这一结果是基于三年间四次休息5分钟后的常规血压抽查得出的。对高血压前期的一种更苛刻的方法，1904年可视化，今天更可行，2即从时间生物学的角度解释，每半小时全天候记录7天的血压和心率，2揭示了心血管疾病风险的持续增加，与每日血压波动的过度幅度有关，这与最合适的24小时余弦曲线的双振幅评估，与性别和年龄指定的标准：昼夜超幅-张力有关。2在自发性高血压卒中易感大鼠3和人类中，昼夜血压幅度的增加可以先于24小时血压中线节律估计统计量(MESOR，昼夜节律调整平均值)的增加，4构成纵向可检测到的真正的高血压前期。无论血压MESOR是什么，昼夜高幅血压、整体昼夜脉压升高和昼夜心率变异性降低(与可接受的变异性相比)都可能在未来6年内将心血管疾病风险从4%增加到100%(图1)。这些无声的风险和昼夜血压的奇怪时机，但没有心率节律，即使在没有高血压的情况下也是巨大的。它们通常可以通过非药物(松弛)或药物(在时间、种类和剂量上指定)的方法来逆转，特别是昼夜高幅紧张的风险，当它发生时，可以发现干预的需要。2然而，所有这些都不可能在办公室访问期间或在传统的24小时记录中找到和执行。时间生物学解释的24小时血压和心率监测，最好但不一定是7天，2用于治疗构成变异性揭示的高血压前期的昼夜高振幅-张力，并在其合并未经治疗或治疗的MESOR高血压时治疗昼夜高振幅-张力。如图2所示，时间生物学对以下方面有帮助：
A systolic blood pressure of 120 to 139 mm Hg and a diastolic blood pressure of 80 to 89 mm Hg, usually considered normal yet described as prehypertensive, are associated with an elevated risk of cardiovascular disease. 1 This result is based on conventional spot-checks of blood pressure after 5 minutes of rest on 4 occasions 3 years apart. A more demanding approach to prehypertension, visualized in 1904 and more practicable today, 2 that is, a half-hourly around-the-clock record of blood pressure and heart rate for 7 days, interpreted chronobiologically, 2 reveals a persistent increase in cardiovascular disease risk associated with an excessive extent of daily blood pressure swing assessed by the double amplitude of the bestfitting 24-hour cosine curve, in relation to gender-and age-specified standards: circadian hyper-amplitude-tension. 2 An increase in circadian blood pressure amplitude can precede an increase in 24-hour blood pressure midline estimating statistic of rhythm (MESOR, a circadian rhythm-adjusted mean) in spontaneously hypertensive stroke-prone rats3 and in humans, 4 constituting a longitudinally detectable real prehypertension. Whatever the blood pressure MESOR may be, circadian hyper-amplitude-tension, with an overall circadian elevation of pulse pressure, and a decreased circadian heart rate variability (compared with an acceptable variability) can increase cardiovascular disease risk in the next 6 years from 4% to 100%(Figure 1). These silent risks and an odd timing of the circadian blood pressure, but not heart rate rhythms, are great, even in the absence of hypertension. They can often be reversed, notably the risk of circadian hyper-amplitude-tension, by a nondrug (relaxation) or drug (specified in timing and in kind and dose) approach, and the need for intervention can be found when it occurs. 2 Yet all this is impossible to find and implement during office visits or in a conventionally interpreted 24-hour record. Chronobiologically interpreted 24-hour blood pressure and heart rate monitoring, preferably but not necessarily for 7 days, 2 serves to treat circadian hyper-amplitude-tension when it constitutes variability-revealed prehypertension and to treat circadian hyper-amplitude-tension when it complicates untreated or treated MESOR hypertension. As shown in Figure 2, chronobiology helps for the following:
血压的昼夜振幅在预测高血压心脏受累中的有用性。
DOI：
--
发表时间：
1992
期刊：
Chronobiologia
影响因子：
--
作者：
Y. Kumagai;T. Shiga;K. Sunaga;G. Cornelissen;A. Ebihara;F. Halberg
通讯作者：
F. Halberg
日程安排变化、生活质量和数量——以小鼠血压升高和节肢动物寿命为模型。
DOI：
--
发表时间：
1979
期刊：
International journal of chronobiology
影响因子：
--
作者：
J. Halberg;E. Halberg;Hayes Dk;Smith Rd;F. Halberg;Delea Cs;Danielson Rs;Bartter Fc
通讯作者：
Bartter Fc
影响因子：
5.9
作者：
Kshirsagar, AV;Carpenter, M;Colindres, RE
通讯作者：
Colindres, RE