Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.
Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.
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DOI：
10.1111/psyp.13796
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发表时间：
2021-07
期刊：
影响因子：
3.7
通讯作者：
Fabiani M
中科院分区：
文献类型：
--
作者：
Zimmerman B;Rypma B;Gratton G;Fabiani M
衰老过程包括细胞生物学的变化，影响细胞与其环境之间的局部相互作用，并最终传播到全身水平。在大脑中，神经元严重依赖于氧气和葡萄糖的有效和动态供应，大脑实质和脑血管系统之间复杂相互作用的年龄相关变化会对健康和功能产生影响，从而对认知产生负面影响并在病理学中发挥作用。因此，脑血管健康被认为是健康生活方式（例如习惯性心肺运动和健康饮食）可以改善衰老认知结果的主要机制之一。本综述旨在详细说明脑血管系统的生理学如何随年龄变化，以及这些变化如何导致认知维持或下降的不同轨迹。这提供了一个框架，用于生成有关所提出的干预措施和有助于增强认知健康的生活方式协变量的功效的具体机制假设。最后，我们讨论了脑血管系统与年龄相关的变化对人类认知神经科学研究的方法学影响，并为未来旨在研究生理学和认知机制之间关系的年龄相关变化的实验提出了方向。在这篇综合综述中，我们详细讨论了脑血管系统如何随年龄变化的生理学，以及这些变化如何导致认知结果的差异。该综述提供了一个框架，用于生成关于所提出的干预措施和生活方式协变量的功效的机制假设，这些干预措施和生活方式协变量有助于增强衰老过程中的认知健康，并讨论了与脑血管生理学相关的人类认知衰老研究中的方法学问题。
The process of aging includes changes in cellular biology that affect local interactions between cells and their environments and eventually propagate to systemic levels. In the brain, where neurons critically depend on an efficient and dynamic supply of oxygen and glucose, age‐related changes in the complex interaction between the brain parenchyma and the cerebrovasculature have effects on health and functioning that negatively impact cognition and play a role in pathology. Thus, cerebrovascular health is considered one of the main mechanisms by which a healthy lifestyle, such as habitual cardiorespiratory exercise and a healthful diet, could lead to improved cognitive outcomes with aging. This review aims at detailing how the physiology of the cerebral vascular system changes with age and how these changes lead to differential trajectories of cognitive maintenance or decline. This provides a framework for generating specific mechanistic hypotheses about the efficacy of proposed interventions and lifestyle covariates that contribute to enhanced cognitive well‐being. Finally, we discuss the methodological implications of age‐related changes in the cerebral vasculature for human cognitive neuroscience research and propose directions for future experiments aimed at investigating age‐related changes in the relationship between physiology and cognitive mechanisms. In this comprehensive review, we discuss, in detail, the physiology of how the cerebrovasculature can change with age and how these changes lead to differences in cognitive outcomes. The review provides a framework for generating mechanistic hypotheses about the efficacy of proposed interventions and lifestyle covariates that contribute to enhanced cognitive well‐being in aging and discusses methodological issues in human cognitive aging research related to cerebrovascular physiology.
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DOI：
10.1073/pnas.0808698106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Argaw, Azeb Tadesse;Gurfein, Blake T.;John, Gareth R.
通讯作者：
John, Gareth R.
影响因子：
4.2
作者：
BLACK, JE;POLINSKY, M;GREENOUGH, WT
通讯作者：
GREENOUGH, WT
影响因子：
6.3
作者：
Aanerud, Joel;Borghammer, Per;Gjedde, Albert
通讯作者：
Gjedde, Albert
影响因子：
--
作者：
Blacher, J;Staessen, JA;Safar, ME
通讯作者：
Safar, ME
影响因子：
2.4
作者：
Alwatban, Mohammed;Murman, Daniel L.;Bashford, Greg
通讯作者：
Bashford, Greg