Dependence of DCE-MRI biomarker values on analysis algorithm.
Dependence of DCE-MRI biomarker values on analysis algorithm.
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DOI：
10.1371/journal.pone.0130168
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Jackson EF
中科院分区：
文献类型：
--
作者：
Ng CS;Wei W;Bankson JA;Ravoori MK;Han L;Brammer DW;Klumpp S;Waterton JC;Jackson EF
动态对比增强MRI（DCE-MRI）生物标志物已被证明可用于肿瘤微血管灌注和渗透性评价，但由于方法学差异，目前尚不清楚不同中心的测量结果是否具有可比性。评价DCE-MRI生物标志物常用分析方法如何影响绝对参数值和重复性。在12只携带C6异种移植物的大鼠中连续三天进行DCE-MRI。采用以下方法计算内皮转移常数（K transs）、细胞外血管外间隙体积分数（v e）和造影剂反流率常数（k ep）：（“Tofts”或“标准凯蒂”）与3参数（“一般动力学”或“扩展凯蒂”）房室模型（包括具有3参数模型的血浆体积分数（vp））;个体与基于群体的血管输入函数（VIF）;以及逐像素与整个肿瘤ROI。通过受试者内变异系数（wCV）和方差分量分析评价变异性。通过分析方法，DCE-MRI绝对参数值和wCV变化很大。绝对参数值范围如下：中位K transs，0.09-0.18 min-1; k ep，0.51-0.92 min-1; v e，0.17-0.23;和v p，0.02-0.04。通过分析方法，wCV也有很大差异，如下所示：平均K trans，32.9-61.9%; k ep，11.6-41.9%; v e，16.1-54.9%;和v p，53.9- 77.2%。3参数建模的K transs和k ep值低于2参数建模（p<0.0001）;像素ROI分析的k ep和v p低于整体ROI分析（p<0.0006）。v-e的wCV显著较小，k-ep的wCV显著较大，基于个体的VIF大于基于群体的VIF。DCE-MRI参数值和可重复性因分析方法而异。不同研究之间DCE-MRI生物标志物的绝对值不太可能具有可比性，除非仔细标准化分析。
Dynamic contrast-enhanced MRI (DCE-MRI) biomarkers have proven utility in tumors in evaluating microvascular perfusion and permeability, but it is unclear whether measurements made in different centers are comparable due to methodological differences. To evaluate how commonly utilized analytical methods for DCE-MRI biomarkers affect both the absolute parameter values and repeatability. DCE-MRI was performed on three consecutive days in twelve rats bearing C6 xenografts. Endothelial transfer constant (K trans), extracellular extravascular space volume fraction (v e), and contrast agent reflux rate constant (k ep) measures were computed using: 2-parameter (“Tofts” or “standard Kety”) vs. 3-parameter (“General Kinetic” or “extended Kety”) compartmental models (including blood plasma volume fraction (v p) with 3-parameter models); individual- vs. population-based vascular input functions (VIFs); and pixel-by-pixel vs. whole tumor-ROI. Variability was evaluated by within-subject coefficient of variation (wCV) and variance components analyses. DCE-MRI absolute parameter values and wCVs varied widely by analytical method. Absolute parameter values ranged, as follows, median K trans, 0.09–0.18 min-1; k ep, 0.51–0.92 min-1; v e, 0.17–0.23; and v p, 0.02–0.04. wCVs also varied widely by analytical method, as follows: mean K trans, 32.9–61.9%; k ep, 11.6–41.9%; v e, 16.1–54.9%; and v p, 53.9–77.2%. K trans and k ep values were lower with 3- than 2-parameter modeling (p<0.0001); k ep and v p were lower with pixel- than whole-ROI analyses (p<0.0006). wCVs were significantly smaller for v e, and larger for k ep, with individual- than population-based VIFs. DCE-MRI parameter values and repeatability can vary widely by analytical methodology. Absolute values of DCE-MRI biomarkers are unlikely to be comparable between different studies unless analyses are carefully standardized.
影响因子：
4.4
作者：
Ragan, Dustin K.;Bankson, James A.
通讯作者：
Bankson, James A.