Exosomes and breast cancer drug resistance.
Exosomes and breast cancer drug resistance.
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外泌体与乳腺癌耐药性
DOI：
10.1038/s41419-020-03189-z
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发表时间：
2020-11-17
影响因子：
9
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Dong X;Bai X;Ni J;Zhang H;Duan W;Graham P;Li Y
耐药是乳腺癌治疗中一个令人生畏的挑战。外泌体作为肿瘤微环境中的细胞间交流载体，在BC的进展中起着重要作用。随着对肿瘤异质性认识的深入，外泌体在耐药中的新作用引起了广泛关注。肿瘤和基质细胞分泌的外泌体中含有的功能蛋白或非编码rna通过调节药物外排和代谢、促生存信号、上皮-间充质转化、茎样特性和肿瘤微环境重塑来介导耐药。在这篇综述中，我们总结了外泌体与BC耐药之间的潜在联系，并讨论了外泌体的独特生物发生、外泌体货物的变化以及BC细胞对药物治疗的释放模式。此外，我们建议外泌体作为预测和监测BC治疗药物反应的候选生物标志物，并作为逆转BC耐药的潜在靶点或载体。
Drug resistance is a daunting challenge in the treatment of breast cancer (BC). Exosomes, as intercellular communicative vectors in the tumor microenvironment, play an important role in BC progression. With the in-depth understanding of tumor heterogeneity, an emerging role of exosomes in drug resistance has attracted extensive attention. The functional proteins or non-coding RNAs contained in exosomes secreted from tumor and stromal cells mediate drug resistance by regulating drug efflux and metabolism, pro-survival signaling, epithelial–mesenchymal transition, stem-like property, and tumor microenvironmental remodeling. In this review, we summarize the underlying associations between exosomes and drug resistance of BC and discuss the unique biogenesis of exosomes, the change of exosome cargo, and the pattern of release by BC cells in response to drug treatment. Moreover, we propose exosome as a candidate biomarker in predicting and monitoring the therapeutic drug response of BC and as a potential target or carrier to reverse the drug resistance of BC.
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影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
影响因子：
4.5
作者：
Aqil, Farrukh;Munagala, Radha;Gupta, Ramesh
通讯作者：
Gupta, Ramesh
影响因子：
2.5
作者：
Bigagli, Elisabetta;Cinci, Lorenzo;Luceri, Cristina
通讯作者：
Luceri, Cristina
影响因子：
168.9
作者：
Davies, C.;Godwin, J.;Gray, R.;Clarke, M.;Darby, S.;McGale, P.;Wang, Y. C.;Peto, R.;Pan, H. C.;Cutter, D.;Taylor, C.;Ingle, J.
通讯作者：
Ingle, J.
影响因子：
50.3
作者：
Bardelli, Alberto;Pantel, Klaus
通讯作者：
Pantel, Klaus