Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis.
Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis.
复制标题
月经和子宫内膜异位症中的卵巢激素-自噬-免疫轴。
作者：
Shen HH;Zhang T;Yang HL;Lai ZZ;Zhou WJ;Mei J;Shi JW;Zhu R;Xu FY;Li DJ;Ye JF;Li MQ
月经发生在少数物种中，涉及在卵巢激素控制下的增殖、分解和再生的循环过程。正常子宫内膜生理学的知识，因为它涉及到月经的调节，是必不可少的理解月经紊乱。越来越多的证据表明，在卵巢激素的调节下，子宫内膜的自噬可导致免疫细胞的浸润，在月经期间子宫内膜脱落、组织修复和预防感染中起着不可或缺的作用。此外，异常的自噬水平，以及由此导致的免疫系统功能失调，与子宫内膜异位症的发病和进展有关。考虑到自噬作为治疗月经相关和子宫内膜相关疾病的靶点的潜在价值，我们综述了自噬在月经周期中的活动和功能。本文还讨论了雌激素/孕激素-自噬-免疫轴在子宫内膜异位症中的作用。
Menstruation occurs in few species and involves a cyclic process of proliferation, breakdown and regeneration under the control of ovarian hormones. Knowledge of normal endometrial physiology, as it pertains to the regulation of menstruation, is essential to understand disorders of menstruation. Accumulating evidence indicates that autophagy in the endometrium, under the regulation of ovarian hormones, can result in the infiltration of immune cells, which plays an indispensable role in the endometrium shedding, tissue repair and prevention of infections during menstruation. In addition, abnormal autophagy levels, together with resulting dysregulated immune system function, are associated with the pathogenesis and progression of endometriosis. Considering its potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders, we review the activity and function of autophagy during menstrual cycles. The role of the estrogen/progesterone-autophagy-immunity axis in endometriosis are also discussed.
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